Pyridine, 3-bromo-6-methoxy-2,4-dimethyl- (9CI) synthesis
- Product Name:Pyridine, 3-bromo-6-methoxy-2,4-dimethyl- (9CI)
- CAS Number:819069-57-3
- Molecular formula:C8H10BrNO
- Molecular Weight:216.08
918145-29-6
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124-41-4
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819069-57-3
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Yield:819069-57-3 94%
Reaction Conditions:
in methanol at 100; for 2 h;
Steps:
87.1 Step 1: Synthesis of 3-bromo-6-methoxy-2,4-dimethyl-pyridine
A mixture of 3-bromo-6-chloro-2,4-dimethyl-pyridine (900 mg, 4.08 mmol) and sodium methanolate in methanol (9.0 mL, 30% w/w in methanol) was stirred at 100 °C for 2 hours. After cooling to room temperature, the reaction mixture was quenched with water and extracted with ethyl acetate three times. The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the title compound as a light yellow oil. Yield: 830 mg, 94%. LCMS (ESI) m/z: 215.9 (M+H).
References:
WO2022/109492,2022,A1 Location in patent:Page/Page column 379
89694-55-3
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74-88-4
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819069-57-3
38 suppliers
$65.00/10mg
89694-55-3
16 suppliers
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74-88-4
349 suppliers
$15.00/10g
819069-57-3
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$65.00/10mg
89856-44-0
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819069-57-3
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5407-87-4
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819069-57-3
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