ChemicalBook CAS DataBase List Glycerol formal

Glycerol formal synthesis

11synthesis methods

Product Name:Glycerol formal
CAS Number:4740-78-7
Molecular formula:C4H8O3
Molecular Weight:104.1

Glycerol formal is used as a dye emulsifier and as a cosolvent for drug delivery. It was prepared from Glycerol and Paraformaldehyde by stirring in water with ferric nitrate at 80℃ for 5 h .

50-00-0 Synthesis

50-00-0
879 suppliers
$10.00/25g

56-81-5 Synthesis

56-81-5
1680 suppliers
$5.00/25g

5464-28-8 Synthesis

5464-28-8
124 suppliers
$7.00/5g

4740-78-7
245 suppliers
$5.00/10g

Yield:4740-78-7 95.6%

Reaction Conditions:

with dihydrogen peroxide;nitric acid;cetyltrimethylammonim bromide;ferric nitrate in water at 80; for 5 h;Reagent/catalyst;Temperature;

Steps:

3; 4; 1 example 4
Will be 920g of glycerin,990gParaformaldehyde and20 g of the supported solid super acid catalyst prepared in Example 2 was addedIn the reaction device, the reaction is heated to 80 ° C, and the water having a lower boiling point and the trioxane formed in the reaction process enters the fractionation device.According to the principle that the boiling point of paraformaldehyde is lower than water, the triacetal is fractionated back to the reaction unit through a fractionation device.The reaction was carried out as a raw material, and the reaction was completed for 5 hours to obtain glycerol formal, and the product was analyzed by HPLC-MS.At 96.3%, the ratio of the six-membered ring product to the product of the five-membered ring in the product was 70:25.

References:

Zhejiang Haotang Industrial Co., Ltd.;Liu Demin CN109535122, 2019, A Location in patent:Paragraph 0029-0034

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