1,3-O-Benzylidene-D-arabitol synthesis
- Product Name:1,3-O-Benzylidene-D-arabitol
- CAS Number:70831-50-4
- Molecular formula:C12H16O5
- Molecular Weight:240.25
488-82-4
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Yield:70831-50-4 82%
Reaction Conditions:
with toluene-4-sulfonic acid in N,N-dimethyl-formamide at 40; for 8 h;
Steps:
1 1,3-O-benzylidene-D-arabinitol (2)
Of the synthesis of 2.0 mmol of D-arabinitol,2.1 mmol of benzaldehyde dimethyl acetal,10 mg p-toluenesulfonic acid was dissolved in 20 mL of DMF,In the decompression, 40 degrees Celsius conditions for 8 hours,After completion of the reaction, triethylamine was neutralized,The crude product obtained by distillation of DMF under reduced pressure was subjected to column chromatography using petroleum ether: ethyl acetate = 3: 1 (V: V)The corresponding pale yellow product was obtained in 82% yield.
References:
CN103848825,2017,B Location in patent:Paragraph 0071; 0072; 0073
