4-(Chloromethyl)tolunitrile synthesis
- Product Name:4-(Chloromethyl)tolunitrile
- CAS Number:874-86-2
- Molecular formula:C8H6ClN
- Molecular Weight:151.59
1592-20-7
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874-86-2
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Yield:874-86-2 96.2%
Reaction Conditions:
with formic acid;5,10,15,20‐tetrakis‐(4‐sulfonatophenyl)‐porphyrin‐iron(III) chloride;sodium nitrite in acetonitrile at 70; for 4.5 h;
Steps:
14 Synthesis of chloromethyl benzonitrile
To the reaction tube were added 0.4 mmol of p-chloromethylstyrene, 2 mmol of sodium nitrite,5 mg of metallic iron (III) porphyrin, 4.5 ml of acetonitrile solvent, heated and stirred at 70 ° C in an air atmosphere,0.5 ml of formic acid was added dropwise within the first 0.5 hours, and after 4 hours of reaction, heating and stirring were stopped, and the mixture was cooled to room temperature,The crude product was obtained by rotary evaporator, and then purified by column chromatography to give the desired product,The column eluant used was a mixed solvent of petroleum ether and ethyl acetate.The p-chloromethylbenzonitrile structure is shown below:The compound was a white solid with a yield of 96.2% and its nuclear magnetic data was as follows
References:
CN107573259,2018,A Location in patent:Paragraph 0133-0137
17201-43-3
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874-86-2
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