午夜插插,噜噜噜影院,啪啪伊人网,欧美熟夫,景甜吻戏视频,男人强操性感蕾丝美女视频在线网站,日本美女跳舞视频

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 4,4'-(Chloromethylene)-bis-benzonitrile
112809-57-1

4,4'-(Chloromethylene)-bis-benzonitrile synthesis

1synthesis methods
-

Yield:112809-57-1 85%

Reaction Conditions:

with hydrogenchloride;zinc(II) chloride in water;toluene at 40 - 65; for 4 h;

Steps:

3

EXAMPLE 3 This example demonstrates a method of preparing chloro-bis-(4-cyanophenyl)-methane. A three-necked round-bottom flask equipped with a mechanical stirrer, a nitrogen inlet and a reflux condenser was charged with toluene (240 ml) and zinc chloride (34 g, 2 eq.). The mixture was stirred at 40° C. while HCl (37%, 60 ml, 5.64 eq.) was added in one portion, followed by the addition of bis-(4-cyanophenyl)-methanol (30 g, 0.128 mole). The reaction mixture was heated to 65° C. for 4 hours. Next, the reaction mixture was cooled to room temperature, water was added (60 ml), and stirring was maintained for 5 minutes. The two layers were separated and the organic phase was washed with an aqueous solution of 2.5% sodium carbonate (120 ml), then with water (60 ml). Toluene was distilled off under reduced pressure (about 180 ml) and the solution was cooled to 40° C. Hexane was added (120 ml) and the mixture was cooled to room temperature and stirring was maintained for about 0.5 hour. Then, the mixture was cooled to about 5° C. and stirring was maintained for additional 3 hours. The crude solid product was obtained by filtration (27.4 g) in 85% yield, having a purity of 98% (by HPLC).

References:

US2007/112202,2007,A1 Location in patent:Page/Page column 7

4,4'-(Chloromethylene)-bis-benzonitrile Related Search: