4-Bromo-1-fluoro-2-nitrobenzene synthesis
- Product Name:4-Bromo-1-fluoro-2-nitrobenzene
- CAS Number:364-73-8
- Molecular formula:C6H3BrFNO2
- Molecular Weight:220
1493-27-2
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$5.00/10g
364-73-8
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$8.00/10g
Yield:364-73-8 97.1%
Reaction Conditions:
with N-Bromosuccinimide;acetic acid at 15;
Steps:
1 (1) Upper bromine reaction:
200 g of o-fluoronitrobenzene and 1000 mL of solvent acetic acid were added to the reaction vessel.The temperature was controlled at about 15 degrees, and 268 g of the bromine reagent N-bromosuccinimide was added in portions.After the addition is completed, stir for a while, GC tracking,Until the reaction is completed. After the reaction is completed, the ice water is hydrolyzed and filtered.Obtained an off-white solid 5-bromo-2-fluoronitrobenzene303 g,97% purity,The yield was 97.1%.
References:
Changzhou University;Chen Xingquan;Dong Yanmin CN109354569, 2019, A Location in patent:Paragraph 0010; 0013
364-76-1
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364-73-8
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7697-37-2
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460-00-4
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40466-95-3
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364-73-8
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446-09-3
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586-78-7
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