4-bromo-2,6-dinitrophenol synthesis

14synthesis methods

Product Name:4-bromo-2,6-dinitrophenol
CAS Number:40466-95-3
Molecular formula:C6H3BrN2O5
Molecular Weight:263.0024

7693-52-9 Synthesis

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Yield:40466-95-3 53%

Reaction Conditions:

with nitric acid in dichloromethane at 0 - 20; for 3 h;

Steps:

3

4-Bromo-2-nitrophenol (3.0 g, 13.8 mmol)Was added to dichloromethane (70 mL)And cooled to 0 ° C.Fuming nitric acid (1.5 M, 20 mL, 30 mmol)And the mixture was stirred at room temperature for 3 hours.Subsequently, the reaction mixture was added to ice water, and the organic layer was extracted with chloroform. After adding magnesium sulfate to the organic layer and stirring, a filtrate was obtained, and the solvent was distilled off under reduced pressure from the filtrate to obtain 4-bromo-2,6-dinitrophenol as an orange solid (1. 9 g, 53%).

References:

JP2016/147939,2016,A Location in patent:Paragraph 0064; 0065