ChemicalBook CAS DataBase List 1-BROMO-4-FLUORO-2-NITROBENZENE

1-BROMO-4-FLUORO-2-NITROBENZENE synthesis

12synthesis methods

Product Name:1-BROMO-4-FLUORO-2-NITROBENZENE
CAS Number:446-09-3
Molecular formula:C6H3BrFNO2
Molecular Weight:220

364-78-3 Synthesis

364-78-3
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446-09-3
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$7.00/5g

Yield:446-09-3 79.5%

Reaction Conditions:

Stage #1:2-nitro-4-fluoroaniline with sulfuric acid;sodium nitrite in water at 10 - 20;Large scale;
Stage #2: with hydrogen bromide;copper(I) bromide in water at 40 - 45;Large scale;

Steps:

1.3; 2.3 Bromine reaction on diazo
Add 1100 g of 2-nitro-4-fluoroaniline to the reaction vessel, add about 30% of sulfuric acid 12000 g, stir, then add a solution of 600 g of sodium nitrite and 2000 mL of water, and add dropwise. The temperature is controlled at 10 to 20 ° C. After the addition is completed, the mixture is stirred for a period of time to prepare a diazonium salt for use.Add 240 g of cuprous bromide and 1800 g of hydrobromic acid to another reaction flask.Stir and control the temperature range of 40 ~ 45 °C to add the above diazonium salt, add, continue to stir,Keep the reaction for a period of time, let cool, add dichloroethane, stir, separate the liquid, and steam,1225 g of 2-nitro-4-fluorobromobenzene was obtained as a brown solid, the content was 98%, and the yield was 79.5%

References:

Changzhou University;Chen Xingquan;Dong Yanmin CN109553534, 2019, A Location in patent:Paragraph 0014; 0016; 0017; 0021; 0023; 0024

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