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Journal of toxicology. Clinical toxicology

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Baclofen withdrawal following removal of an intrathecal baclofen pump despite oral baclofen replacement.

Published:1 January 2003 DOI: 10.1081/clt-120018277 PMID: 12645974
Michael I Greenberg, Robert G Hendrickson

Abstract

Intrathecal baclofen is used as a muscle relaxant and antispasmodic in cases of spasticity resulting from central nervous system trauma. The baclofen withdrawal syndrome may include hyperthermia, tachycardia, hypertension, seizures, altered mental status, and psychomotor agitation. We report a case in which the removal of a baclofen pump lead tothe development of severe withdrawal symptoms despite oral baclofen replacement therapy. In order to avoid the development of withdrawal, adequate doses of GABA agonist agents should be administered immediately prior to, and following, baclofen pump removal.

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