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Neurology

Neurology

IF: 7.7
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Comparison of L-baclofen and racemic baclofen in trigeminal neuralgia.

Published:1 November 1987 DOI: 10.1212/wnl.37.11.1725 PMID: 3313099
G H Fromm, C F Terrence

Abstract

L-Baclofen was compared with racemic baclofen (Lioresal) in a double-blind crossover trial in 15 patients with typical trigeminal neuralgia. L-Baclofen was more effective than five times as much racemic baclofen in nine patients. Six of these nine patients have continued pain-free on L-baclofen for 4 to 17 months (mean, 10 months). L-Baclofen was much better tolerated than racemic baclofen. Our results suggest that L-baclofen represents a significant improvement over racemic baclofen in the treatment of trigeminal neuralgia, and support our laboratory observations indicating that D-baclofen antagonizes the action of L-baclofen.

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Baclofen 1134-47-0 C10H12ClNO2 558 suppliers $11.00-$1250.00
(R)-Baclofen 69308-37-8 C10H12ClNO2 181 suppliers $15.00-$800.00
Baclofen impurity 6 28311-44-6 C10H13NO3 9 suppliers Inquiry

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