醋酸洗必太
中文名稱 | 醋酸洗必太 |
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中文同義詞 | 醋酸氟卡胺;醋酸洗必太/ 醋酸氟卡尼/乙酸氟卡尼/ N-(哌啶-2-基甲基)-2,5-二(2,2,2-三氟乙氧基)苯甲酰胺乙酸鹽;醋酸洗必太;醋酸氟卡尼;乙酸氟卡尼;氟卡尼醋酸鹽;氟卡尼系統(tǒng)適應(yīng)性 EP標(biāo)準(zhǔn)品;醋酸氟卡尼 USP標(biāo)準(zhǔn)品 |
英文名稱 | FLECAINIDE ACETATE |
英文同義詞 | 2,5-bis-(2,2,2-trifluoroethoxy)-n-(2-piperidinylmethyl)benzamideacetate;n-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamidemonoacetate;n-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-benzamidmonoacetate;r-818;N-(2-PIPERIDYLMETHYL)-2,5-BIS-(2,2,2-TRIFLUOROETHOXY)BENZAMIDE ACETATE;N-[2-PIPERIDYLMETHYL]-2,5-BIS-[2,2,2-TRIFLUOROETHOXY]BENZAMIDE ACETATE SALT;FLECAINIDE ACETATE;FLECAINIDE ACETATE SALT |
CAS號(hào) | 54143-56-5 |
分子式 | C19H24F6N2O5 |
分子量 | 474.39 |
EINECS號(hào) | 258-997-5 |
相關(guān)類別 | 原料藥;中間體;藥物分子;Organics |
Mol文件 | 54143-56-5.mol |
結(jié)構(gòu)式 | ![]() |
醋酸洗必太 性質(zhì)
熔點(diǎn) | 145-147℃ |
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儲(chǔ)存條件 | 2-8°C |
溶解度 | 易溶于水和無水乙醇。易溶于稀醋酸,幾乎不溶于稀鹽酸。 |
形態(tài) | 固體 |
顏色 | 白色 |
水溶解性 | Soluble in dilute acetic acid, dimethyl sulfoxide, ethanol, methanol and water. |
穩(wěn)定性 | 自購買之日起 1 年內(nèi)保持穩(wěn)定。 DMSO 或蒸餾水中的溶液可在 -20°C 下儲(chǔ)存長達(dá) 1 個(gè)月。 |
Nav1.5 channel
Flecainide is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia. Flecainide works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential. in vitro: Under the current-clamp condition, flecainide (1-100 microM) prolonged the action potential duration at both the early and the late phases of repolarization in a concentration-dependent manner without affecting the resting membrane potential [1]. At a holding potential (HP) of -120 mV, flecainide use-dependently blocked WT and G1306E I(Na) equally but was more potent on R1448C channels. For WT, the extent of block depended on a holding voltage more negative than the activation threshold, being greater at -90 mV as compared to -120 and -180 mV [2]. in vivo: Flecainide (80-130 mg/m(2) orally) resulted in termination of the tachycardia in all 8 patients. Acute pharmacological termination of arrhythmia occurred with oral flecainide loading in 1 and temporarily with intravenous esmolol loading in 1 patient. Adjuvant therapy in form of propranolol was used in 5 and digoxin in 2 [3].
安全信息
危險(xiǎn)品標(biāo)志 | Xn |
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危險(xiǎn)類別碼 | 22-36/37/38-63 |
安全說明 | 22-26-36/37/39-45-46 |
危險(xiǎn)品運(yùn)輸編號(hào) | 3249 |
WGK Germany | - |
RTECS號(hào) | CV5792550 |
危險(xiǎn)等級 | 6.1(b) |
包裝類別 | III |
海關(guān)編碼 | 2933399090 |
提供商 | 語言 |
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英文
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更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
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2025/02/08 | HY-17429 | 醋酸洗必太 Flecainide acetate | 54143-56-5 | 5 mg | 290元 |
2025/02/08 | HY-17429 | 醋酸洗必太 Flecainide acetate | 54143-56-5 | 10mg | 465元 |