巨大戟醇-3-O-當(dāng)歸酸酯
| 中文名稱 | 巨大戟醇-3-O-當(dāng)歸酸酯 |
|---|---|
| 中文同義詞 | 巨大戟醇-3-O-當(dāng)歸酸酯;3-當(dāng)歸酰巨大戟萜醇;巨大戟醇-3-當(dāng)歸酸酯;巨大戟醇甲基丁烯酸酯, >98%;巨大戟醇-3-O-當(dāng)歸酸酯(巨大戟醇甲基丁烯酸酯);(Z)-(1AR,2S,5R,5AS,6S,8AS,9R,10AR)-5,5A-二羥基-4-(羥甲基)-1,1,7,9-四甲基-11-氧代-1A,2,5,5A,6,9,10,10A-八氫-1H-2,8A-甲基環(huán)戊烷并[A]環(huán)丙烷[E][10]輪烯-6-基 2-甲基-2-烯酸酯;巨大戟醇-3-O-當(dāng)歸酸酯/HPLC;INGENOL-3-ANGELATE,PKC活化劑 |
| 英文名稱 | Ingenol mebutate |
| 英文同義詞 | Ingenol-3-O-angelate;Picato;(1aR,2S,5R,5aS,6S,8aS,9R,10aR)-5,5a-Dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a- methanocyclopenta(a)cyclopropa(e)cyclodecen-6-yl (2Z)-2-methylbut-2-enoate;Ingenol mebutate;Ingenol Mebutate, >98%;Ingenol 3-mebutate;Ingenol-3-O-angelate 75567-37-2;PEP005; INGENOL MEBUTATE; I3A |
| CAS號(hào) | 75567-37-2 |
| 分子式 | C25H34O6 |
| 分子量 | 430.53 |
| EINECS號(hào) | |
| 相關(guān)類別 | 標(biāo)準(zhǔn)品;植物提取物;天然產(chǎn)物;對照品-中藥對照品;標(biāo)準(zhǔn)品 -中藥標(biāo)準(zhǔn)品;標(biāo)準(zhǔn)品，對照品;標(biāo)準(zhǔn)品-對照品;分析試劑標(biāo)準(zhǔn)品 |
| Mol文件 | 75567-37-2.mol |
| 結(jié)構(gòu)式 |  |
巨大戟醇-3-O-當(dāng)歸酸酯 性質(zhì)
| 沸點(diǎn) | 576.9±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.26±0.1 g/cm3(Predicted) |
| 儲(chǔ)存條件 | -20°C |
| 溶解度 | DMSO：可溶15mg/mL，澄清 |
| 形態(tài) | 粉末 |
| 酸度系數(shù)(pKa) | 11.52±0.70(Predicted) |
| 顏色 | 白色至米色 |
| 生物來源 | semisynthetic |
| 水溶解性 | Soluble in 100% ethanol, DMSO, dichloromethane, and methanol. Insoluble in water. |
| 穩(wěn)定性 | 自購買之日起 1 年內(nèi)保持穩(wěn)定。 DMSO 或乙醇溶液可在 -20°C 下保存長達(dá) 1 個(gè)月。 |
| InChIKey | VDJHFHXMUKFKET-WDUFCVPESA-N |
| SMILES | C(O[C@@H]1[C@@]2(O)[C@H](O)C(CO)=C[C@]3([H])C(=O)[C@]2(C=C1C)[C@H](C)C[C@@]1([H])C(C)(C)[C@]13[H])(=O)/C(/C)=C\C |
|
PKC-β 0.105 nM (Ki) |
PKC-γ 0.162 nM (Ki) |
PKC-ε 0.171 nM (Ki) |
PKC-α 0.3 nM (Ki) |
PKC-δ 0.376 nM (Ki) |
Ingenol Mebutate (Ingenol 3-angelate) is an active ingredient in Euphorbia peplus , acting as a potent PKC activator, with K i s of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively. Ingenol Mebutate also EC 50 s of 13 ± 2.4 nM (PKC-α), 4.37 ± 0.4 nM (PKC-βI), 10.5 ± 2.2 nM (PKC-βII), 38.6 ± 2.9 nM (PKC-δ), 1.08 ± 0.01 nM (PKC-ε), 0.9 ± 0.13 nM (PKC-μ) in WEHI-231 cells, 198 ± 12.5 nM (PKC-α), 69.1 ± 8.2 nM (PKC-βI), 4.6 ± 0.4 nM (PKC-ε) and 1 nM (PKC-μ) in HOP-92 cells, 635 ± 245 nM (PKC-α), 146 ± 35 nM (PKC-βI), 4.7 ± 0.7 nM (PKC-δ), 1.1 ± 0.5 nM (PKC-ε), and 30 nM (PKC-μ) in Colo-205 cells. Ingenol Mebutate sensitizes WEHI-231 cells, HOP-92 and Colo-205 cells, with IC 50 s of 1.41 ± 0.255 nM, 3.24 ± 2.01 nM, and 11.9 ± 1.307 nM, respectively. Ingenol Mebutate (PEP005; 20 nM) actions are PKC-δ dependent, induces apoptosis in primary AML marrow blasts but not in normal myeloblasts. Ingenol Mebutate (PEP005) activates PKCδ and inhibits PKCα. Colo205-R cells (IC 50 : >10 μM) are >300-fold more resistant to Ingenol Mebutate than parental Colo205-S cells.
安全信息
| 毒害物質(zhì)數(shù)據(jù) | 75567-37-2(Hazardous Substances Data) |
|---|
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/05/22 | HY-B0719 | 巨大戟醇-3-O-當(dāng)歸酸酯 Ingenol Mebutate | 75567-37-2 | 1mg | 868元 |
| 2025/05/22 | HY-B0719 | 巨大戟醇-3-O-當(dāng)歸酸酯 Ingenol Mebutate | 75567-37-2 | 10mM * 1mLin DMSO | 2586元 |