3,17-二丙酸-17-BETA-雌二酯
| 中文名稱 | 3,17-二丙酸-17-BETA-雌二酯 |
|---|---|
| 中文同義詞 | 3,17-二丙酸-17-BETA-雌二酯;雌二醇二丙酸酯;3.17二丙酸17Β雌二酯;二丙酸雌二醇;雌二醇 3,17-二丙酸酯;1,3,5(10)-雌甾三烯 3,17Β-二丙酸酯;3,17Β-二羥基-1,3,5(10)-雌三烯 3,17-二丙酸酯;Β-雌二醇 3,17-二丙酸酯 |
| 英文名稱 | 17-BETA-ESTRADIOL 3,17-DIPROPIONATE |
| 英文同義詞 | 3,17-beta-Estradiol dipropionate;3,17-beta-estradioldipropionate;3,17-beta-Oestradiol dipropionate;3,17-beta-oestradioldipropionate;3,17β-estradioldipropionate;Agofollin;b-estradioldipropionate;beta-Oestradiol dipropionate |
| CAS號(hào) | 113-38-2 |
| 分子式 | C24H32O4 |
| 分子量 | 384.51 |
| EINECS號(hào) | 204-026-5 |
| 相關(guān)類別 | 小分子抑制劑;藥物雜質(zhì)及中間體;原料藥;Steroids;APIs |
| Mol文件 | 113-38-2.mol |
| 結(jié)構(gòu)式 |  |
3,17-二丙酸-17-BETA-雌二酯 性質(zhì)
| 熔點(diǎn) | 104-106℃ (ethanol ) |
|---|---|
| 沸點(diǎn) | 431.17°C (rough estimate) |
| 密度 | 1.0474 (rough estimate) |
| 折射率 | 1.4860 (estimate) |
| 溶解度 | 二甲基亞砜：62.5 mg/ml（162.54 mM） |
| 形態(tài) | 粉末晶體 |
| 顏色 | 白色到近乎白色 |
| Merck | 13,3738 |
Estradiol dipropionate (17-Beta-Estradiol-3,17-Dipropionate)是一種半合成的甾體雌激素，用于女性更年期癥狀和低雌激素水平的激素治療，也用于治療婦科疾病。
Treatment of Estradiol dipropionate (2μg per 100 g; single subcutaneous injection) and Chorionic gonadotropin (10 IU per 100 g; sc; twice a day) for 2 days, levels of β-catenin and GSK-3β in luminal and glandular epithelia are lower in Ovariectomized mice.
Treatment of Estradiol dipropionate (2 μg per 100 g; once a week) and Chorionic gonadotropin ((10 IU per 100 g; once a day) for a month, the incidence of atypical endometrial hyperplasia is significantly higher, the level of β-catenin is slightly higher, and the expression of GSK-3β is lower in luminal and glandular epithelia.