阿羅洛爾
| 中文名稱 | 阿羅洛爾 |
|---|---|
| 中文同義詞 | 阿羅洛爾;阿羅洛爾溶液,100PPM;阿羅洛爾溶液,1000PPM;5-(2-((3-(叔丁胺基)-2-羥丙基)硫基)噻唑-4-基)噻吩-2-甲酰胺;化合物 T10371 |
| 英文名稱 | AROTINOLOL |
| 英文同義詞 | AROTINOLOL;Arottnolol;2-(3-tert-Butylamino-2-hydroxypropylthio)-4-(5-carbamoyl-2-thienyl)thiazole;2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-;2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-, (+-)-;NSC 317940;5-[2-[[3-(tert-butylamino)-2-hydroxy-propyl]thio]thiazol-4-yl]thiophene-2-carboxamide;5-[2-[3-(tert-butylamino)-2-hydroxy-propyl]sulfanyl-1,3-thiazol-4-yl]thiophene-2-carboxamide |
| CAS號(hào) | 68377-92-4 |
| 分子式 | C15H21N3O2S3 |
| 分子量 | 371.54 |
| EINECS號(hào) | |
| 相關(guān)類別 | 醫(yī)藥原料藥;降糖降壓產(chǎn)品 |
| Mol文件 | 68377-92-4.mol |
| 結(jié)構(gòu)式 |  |
阿羅洛爾 性質(zhì)
| 熔點(diǎn) | 148-149° |
|---|---|
| 沸點(diǎn) | 599.8±60.0 °C(Predicted) |
| 密度 | 1.35 |
| 儲(chǔ)存條件 | 2-8°C(protect from light) |
| 溶解度 | 可溶于DMSO（少許）、甲醇（少許） |
| 酸度系數(shù)(pKa) | 13.71±0.20(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 灰白色至淺黃色 |
|
5-HT 2A Receptor
|
Arotinolol shows its selectivity of β-adrenergic receptors, the result of Arotinolol for β1 and β2 adrenoceptors in 125 I-ICYP binding to rat cerebral cortical membranes with pK i value of 9.74 and 9.26 respectively. The selectively of β1 and β2 is equal. Arotinolol shows its potency for inhibiting the binding of the same radioligand to 5HT1B-serotonergic receptor site, Arotinolol displaces 125 I-ICYP binding to 5HT1B-receptors with the pK i values of 7.97 and 8.16 resepectively for β1 and β2 adrenergic receptors.
Arotinolol (oral gavage; 200 mg/kg; 8 weeks) can significantly decrease central arterial pressure (CAP) and pulse wave velocity (PWV), in addition, it reduces aortic collagen depositions and finally improves arterial stiffness in SHR mouse.
| Animal Model: | SHR mice |
| Dosage: | 200 mg/kg |
| Administration: | Orally gavage; 200 mg/kg; once daily; 8 weeks |
| Result: | Improved arterial stiffness in SHR. |
安全信息
阿羅洛爾 化學(xué)藥品說(shuō)明書(shū)
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-122537A | 阿羅洛爾 Arotinolol | 68377-92-4 | 5mg | 500元 |
| 2024/11/08 | HY-122537A | 阿羅洛爾 Arotinolol | 68377-92-4 | 10mM * 1mLin DMSO | 550元 |