扁塑藤素
| 中文名稱 | 扁塑藤素 |
|---|---|
| 中文同義詞 | 扁塑藤素 (扁蒴藤素);扁蒴藤素;扁塑藤素;扁塑藤素 標準品;扁塑藤素對照品;標準品對照品】PRISTIMERIN;(2R,4AS,6AS,12BR,14AS,14BR)-10-羥基-2,4A,6A,9,12B,14A-六甲基-11-氧代-1,2,3,4,4A,5,6,6A,11,12B,13,14,14A,14B-十四氫苉-2-羧酸甲酯;扁蒴藤素/HPLC |
| 英文名稱 | pristimerin |
| 英文同義詞 | pristimerin;3-Hydroxy-2-oxo-24-nor-D:A-friedoolean-1(10),3,5,7-tetren-29-oic acid methyl ester;Celastrol-methylether;(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oicacidmethylester;(9b,13a,14b,20a)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tertraen-29-oic acid methyl ester;3-hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid, methyl ester;Celastrol methyl ester;Pristimerin(NSC 99281) |
| CAS號 | 1258-84-0 |
| 分子式 | C30H40O4 |
| 分子量 | 464.64 |
| EINECS號 | 251-228-4 |
| 相關類別 | 對照品,標準品;植物提取物;對照品;標準品;中藥對照品;科研試劑;分析試劑標準品;標準品-對照品;細胞生物學試劑;對照品-中藥對照品;標準品 -中藥標準品;標準品，對照品;醫(yī)藥、農(nóng)藥及染料中間體;蒽醌 |
| Mol文件 | 1258-84-0.mol |
| 結構式 |  |
扁塑藤素 性質(zhì)
| 熔點 | 219.5°C |
|---|---|
| 沸點 | 488.1°C (rough estimate) |
| 密度 | 1.0271 (rough estimate) |
| 折射率 | 1.4800 (estimate) |
| 儲存條件 | -20°C |
| 溶解度 | 二甲基亞砜：≥5mg/mL |
| 形態(tài) | 紅色固體 |
| 酸度系數(shù)(pKa) | 8.60±0.70(Predicted) |
| 顏色 | 橙色 |
| InChIKey | JFACETXYABVHFD-VXTIGNJVNA-N |
| SMILES | [C@]12(C)CC[C@@]3(C)CC[C@@](C)(C(=O)OC)C[C@@]3([H])[C@]1(C)CC[C@@]1(C)C3=CC(C(O)=C(C)C3=CC=C21)=O |&1:0,4,8,15,17,21,r| |
IC50: 93 nM (MGL)
Pristimerin inhibits the activity of purified MGL with an IC 50 of 93±8 nM and that of non-purified MGL (cell lysates of MGL-transfected HeLa cells) with an IC 50 of 398±68 nM. Pristimerin inhibits MGL through a mechanism that is rapid, reversible and non-competitive. The binding of pristimerin to MGL might be strengthened by formation of a polar interaction with a regulatory cysteine, possibly Cys 208 . Pristimerin inhibits HFLS-RA and HUVEC cell viability in a dose- and time-dependent manner. Pristimerin decreases VEGF-induced autophosphorylation of VEGFR2 and attenuates the activation of the VEGF-induced VEGFR2-mediated signaling pathway .
Pristimerin inhibits inflammation and tumor angiogenesis. Pristimerin significantly reduces vessel density in synovial membrane tissues of inflamed joints and reduces the expression of pro-angiogenic factors in sera, including TNF-α, Ang-1, and MMP-9.
安全信息
| 毒性 | LD50 oral in mouse: 8gm/kg |
|---|