WARANGALONE
| 中文名稱 | WARANGALONE |
|---|---|
| 中文同義詞 | 攀登魚藤異黃酮;WARANGALONE攀登魚藤異黃酮 |CAS 4449-55-2;Warangalone試劑;Warangalone試劑 |
| 英文名稱 | warangalone |
| 英文同義詞 | warangalone;5-hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-10-(3-methylbut-2-en-1-yl)pyrano[3,2-g]chromen-4(8H)-one;5-hydroxy-7-(4-hydroxyphenyl)-2,2-dimethyl-10-(3-methylbut-2-enyl)pyrano[3,2-g]chromen-6-one;Scandenolone;2H,6H-Benzo[1,2-b:5,4-b']dipyran-6-one,5-hydroxy-7-(4-hydroxyphenyl)-2,2-dimethyl-10-(3-methyl-2-buten-1-yl)-;Warangalone (Scandenolone);5-hydroxy-7-(4-hydroxyphenyl)-2,2-dimethyl-10-(3-methylbut-2-enyl)-6-pyrano[3,2-g][1]benzopyranone |
| CAS號(hào) | 4449-55-2 |
| 分子式 | C25H24O5 |
| 分子量 | 404.46 |
| EINECS號(hào) | |
| 相關(guān)類別 | 標(biāo)準(zhǔn)品;植物提取物;標(biāo)準(zhǔn)品 -對(duì)照藥材;黃酮 |
| Mol文件 | 4449-55-2.mol |
| 結(jié)構(gòu)式 |  |
WARANGALONE 性質(zhì)
| 熔點(diǎn) | 164-165 °C |
|---|---|
| 沸點(diǎn) | 627.0±55.0 °C(Predicted) |
| 密度 | 1.258±0.06 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Store at -20°C |
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 6.39±0.40(Predicted) |
| 顏色 | 淺黃至黃色 |
IC50: 4.8 μg/mL (3D7), 3.7 μg/mL (K1)
IC50: 3.5 μM (cAK)
Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC 50 s of 4.8 μg/mL and 3.7 μg/mL, respectively. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC 50 of 3.5 μM. When HL-60 cells are exposed to Warangalone (30 μM) for 24 h, Warangalone induces a significant decrease (8%) in cell viability compare to controls. Warangalone also inhibits HL-60 cell growth within 24 h in a time-dependent fashion. A time-dependent increase in caspase-9 activity is observed in Warangalone-treated cells.
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/05/22 | HY-N1074 | WARANGALONE Warangalone | 4449-55-2 | 1mg | 3341元 |