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| | Eflornithine hydrochloride Basic information |
| | Eflornithine hydrochloride Chemical Properties |
| Melting point | 181-184°C | | storage temp. | Store at -20°C | | solubility | H2O: >10 mg/mL, soluble | | form | solid | | color | white | | Water Solubility | Soluble to 75 mM in water | | CAS DataBase Reference | 68278-23-9(CAS DataBase Reference) |
| | Eflornithine hydrochloride Usage And Synthesis |
| Uses | DL-alpha-Difluoromethylornithine Hydrochloride is an irreversible inhibitor of ornithine decarboxylase. | | Uses | Antineoplastic; antiprotozoal. | | Indications | Vaniqa (eflornithine hydrochloride 13.9%) cream is a unique topical cream
that slows anagen hair growth by irreversibly blocking the enzyme ornithine
decarboxylase. This enzyme produces polyamines in the hair matrix that are
partially responsible for the growth of the anagen hair. The cream was tested
only on the upper lip and chin region. The onset of action is usually within 8
weeks of starting the b.i.d. treatment, and the hair growth will return to baseline
within 8 weeks of discontinuing the drug. Patients need to be reminded that this
product does not remove hair but slows its growth in between whatever they use
for hair removal. | | Brand name | Ornidyl (Sanofi Aventis); Vaniqa (Skinmedica). | | in vivo | Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases[1]. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism[2]. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles[3]. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension[4]. | | IC 50 | Trypanosoma | | storage | Desiccate at RT |
| | Eflornithine hydrochloride Preparation Products And Raw materials |
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