L-O-磷酸絲氨酸
中文名稱 | L-O-磷酸絲氨酸 |
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中文同義詞 | L-O-磷酸絲氨酸;L-2-氨基-3-羥基丙酸3-磷酸;L-絲氨酸O-磷酸;O-磷酸-L-絲氨酸;L-絲氨酸O-型磷酸;L-2-氨基-3-羥基丙酸三磷酸;L-O-磷酸絲氨酸;磷酸化絲氨酸 |
英文名稱 | O-Phospho-L-serine |
英文同義詞 | L-O-PHOSPHOSERINE;L-SERINE-O-PHOSPHATE;L-PHOSPHOSERINE;H-SER(PO3H2)-OH;PHOSPHATIDYLETHANOLAMINE(EGG)(RG);O-Phosho-L-serine;O-Phosphorylserine;Phospho-L-serine |
CAS號 | 407-41-0 |
分子式 | C3H8NO6P |
分子量 | 185.07 |
EINECS號 | 206-986-0 |
相關類別 | 酯;小分子抑制劑;有機化工原料;氨基酸衍生物;食品添加劑;生物化工;Amino Acids;Biochemistry;Biological-modified Amino Acids;Glutamate receptor;對照品 |
Mol文件 | 407-41-0.mol |
結(jié)構(gòu)式 | ![]() |
L-O-磷酸絲氨酸 性質(zhì)
熔點 | 190 °C(lit.) |
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比旋光度 | [α]D20 +14~+18°(c=5,dil.HCl) |
沸點 | 475.4±55.0 °C(Predicted) |
密度 | 1.809±0.06 g/cm3(Predicted) |
蒸氣壓 | 0Pa at 20℃ |
儲存條件 | under inert gas |
溶解度 | H2O:50 mg/mL 熱,透明,無色至淺黃色 |
形態(tài) | 結(jié)晶粉末 |
酸度系數(shù)(pKa) | pK1:2.08;pK2:5.65;pK3:9.74 (25°C) |
顏色 | 白色 |
旋光性 (optical activity) | +16.221 (2 mol dm-3 HCl) |
生物來源 | mouse |
水溶解性 | 28.34g/L at 20℃ |
Merck | 14,7363 |
BRN | 1726826 |
InChIKey | BZQFBWGGLXLEPQ-UWTATZPHSA-N |
CAS 數(shù)據(jù)庫 | 407-41-0(CAS DataBase Reference) |
Target | Value |
mGluR
() |
O-Phospho-L-serine (l-SOP) weakly binds to mGluR1, and antagonizes the effects of l-glutamate. l-SOP activates the group III receptors (mGluR4, mGluR6, mGluR7, and mGluR8), but mGluR7 has much lower affinity for l-SOP than the other group III receptors and also displays lower efficacy for both ligands. O-Phospho-L-serine (l-SOP) generates enhanced intracellular calcium responses in mGluR4 transfected cells. l-SOP inhibits the l-glutamate mediated mGluR1 response, with a K i of 1 mM; l-SOP displays a substantially more potent inhibition of mGluR2 activation, with a K i of 1 μM, three orders-of-magnitude more potent than for mGluR1. l-SOP induces membrane potential changes in HEK/TRPC4 cells transfected with mGluR4 or mGluR6. l-SOP induces TRPC4β activation mediated by Gα i/o proteins. O-Phospho-L-serine (L-SOP) inhibits Müller glia proliferation, without affecting light-induced photoreceptor cell death. L-SOP disrupts Müller glia proliferation subsequent to or in parallel with the activation of ascl1a and stat3 expression in the light-damaged retina. L-SOP inhibits cone cell regeneration in the light-damaged retina.
提供商 | 語言 |
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更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
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2025/05/22 | HY-15129R | L-O-磷酸絲氨酸 O-Phospho-L-serine (Standard) | 10 mg | 370元 | |
2025/05/22 | HY-15129 | L-O-磷酸絲氨酸 O-Phospho-L-serine | 407-41-0 | 25 mg | 185元 |