Cyclosporin H
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- CAS-Nr.
- 83602-39-5
- Englisch Name:
- Cyclosporin H
- Synonyma:
- CS-1741;CS-1030;Sandoz 37-839;CYCLOSPORIN H;CsH cyclosporin;Cyclosporin H, >=95%;Cyclosporin impurity H;Cyclosporine IMpurity-H;Cyclosporine Impurity 8;Cyclosporin H, EvoPure?
- CBNumber:
- CB8279114
- Summenformel:
- C62H111N11O12
- Molgewicht:
- 1202.61
- MOL-Datei:
- 83602-39-5.mol
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Cyclosporin H Eigenschaften
- Schmelzpunkt:
- 148-151°C
- Siedepunkt:
- 1293.8±65.0 °C(Predicted)
- Dichte
- 1.016±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- Chloroform (Slightly), Methanol (Slightly, Heated, Sonicated)
- pka
- 13.32±0.70(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
- Optische Aktivit?t
- [α]/D -100 to -115°, c = 0.5 in methanol
Cyclosporin H Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Cyclosporin H is a natural cyclic undecapeptide that selectively antagonizes the formyl peptide receptor at concentrations ranging from 0.1 to 10 μM. Unlike cyclosporin A , cyclosporin H does not bind cyclophilin to evoke an immunosuppressant response. Cyclosporin H has been reported to inhibit phorbol ester-mediated effects in mouse skin and block calcium/calmodulin-dependent EF-2 phosphorylation
in vitro.
Chemische Eigenschaften
White Powder
Verwenden
Cyclosporin H is a minor analogue of the cyclosporin family which is immunologically inactive as it does not bind to immunophilin. Cyclopsorin H is the most extensively investigated of the minor cyclosporin analogues and displays a range of activities. It is a potent inhibitor of tumour-promoting phorbol esters on mouse skin in vivo, and of calcium/calmodulin-dependent EF-2 phosphorylation in vitro, a potent and selective antagonist of formyl peptide receptor and inhibitor of formyl peptide-induced superoxide formation.
Cyclosporin H Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Cyclosporin H Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 176)Lieferanten
83602-39-5()Verwandte Suche:
- CYCLOSPORIN H
- Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-D-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
- 5-(N-Methyl-D-valine)cyclosporin A
- Cyclo[L-alanyl-D-alanyl-N-Methyl-L-
leucyl-N-Methyl-L-leucyl-N-Methyl-D-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-diMethyl-L-2-aMinooctanoyl-L-2-aMinobutanoyl-N-Methylglycyl-N-Methyl-L-leucyl-L-valyl-N-Methyl-L-leucyl]
- Sandoz 37-839
- Cyclosporin H, >=95%
- Cyclosporine IMpurity-H
- 5-(N-Methyl-D-valine)cyclosporine A
- Cyclosporin H, froM MicroMonospora
- Cyclosporin H/Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-D-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
- CS-1741
- CS-1030
- Cyclosporin H, 95%, from Micromonospora
- Cyclosporin Impurity 8(Cyclosporin H)
- Cyclosporin A, 5-(N-methyl-D-valine)-
- Cyclosporine Impurity 8
- (3R,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
- Cyclosporin Impurity HQ: What is
Cyclosporin Impurity H Q: What is the CAS Number of
Cyclosporin Impurity H Q: What is the storage condition of
Cyclosporin Impurity H Q: What are the applications of
Cyclosporin Impurity H
- Cyclosporin impurity H
- Cyclosporin H, EvoPure?
- CsH cyclosporin
- (3R,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
- Cyclosporin H, TPA/PMA inhibitor
- 83602-39-5
- C62H111N11O12
- Intermediates & Fine Chemicals
- Peptides
- Pharmaceuticals
- ACTIVE PHARMACEUTICAL INGREDIENTS
