2-Hydroxybenzamid
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2-Hydroxybenzamid Eigenschaften
- Schmelzpunkt:
- 140-144 °C(lit.)
- Siedepunkt:
- 270°C
- Dichte
- 1,175 g/cm3
- Brechungsindex
- 1.5323 (estimate)
- Flammpunkt:
- 181°C/14mm
- storage temp.
- Inert atmosphere,Room Temperature
- L?slichkeit
- methanol: 0.1 g/mL, clear
- pka
- pKa 8.13(H2O t = 37) (Uncertain)
- Aggregatzustand
- Crystalline Powder
- Farbe
- White
- Geruch (Odor)
- Odorless
- S?ure-Base-Indikators(pH-Indikatoren)
- 5 (0.2% aq soln)
- Wasserl?slichkeit
- <0.1 g/100 mL at 20 ºC
- Decomposition
- 270°C
- Merck
- 14,8328
- BRN
- 742439
- Stabilit?t:
- Stable. Light sensitive. Incompatible with strong bases, strong oxidizing agents.
- InChIKey
- SKZKKFZAGNVIMN-UHFFFAOYSA-N
- LogP
- 1.280
- CAS Datenbank
- 65-45-2(CAS DataBase Reference)
- NIST chemische Informationen
- Benzamide, 2-hydroxy-(65-45-2)
- EPA chemische Informationen
- o-Hydroxybenzamide (65-45-2)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | Xn | ||
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R-S?tze: | 22-36/37/38-20/21/22 | ||
S-S?tze: | 26-36 | ||
RIDADR | 3249 | ||
WGK Germany | 3 | ||
RTECS-Nr. | VN6475000 | ||
TSCA | Yes | ||
HazardClass | 6.1(b) | ||
PackingGroup | III | ||
HS Code | 29214300 | ||
Giftige Stoffe Daten | 65-45-2(Hazardous Substances Data) | ||
Toxizit?t | LD50 orally in mice: 1.4 g/kg (Hart) |
Bildanzeige (GHS) |
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2-Hydroxybenzamid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Salicylamide is less acidic (pKa 8.2) than other salicylic acid derivatives. Although poorly soluble in water, stable solutions can be formed at pH 9 through ionization of the phenolic group. It is absorbed from the GI tract on oral administration and is rapidly metabolized to inactive metabolites by intestinal mucosa, but not by hydrolysis. Activity appears to reside in the intact molecule. It is approximately 40 to 55% plasma protein bound, and it competes with other salicylates and acetaminophen for glucuronide conjugation, decreasing the extent of conjugation of these other drugs.Chemische Eigenschaften
Salicylamide is a odorless white or slightly pink crystals. It is less acidic (pKa 8.2) than other salicylic acid derivatives. Although poorly soluble in water, stable solutions can be formed at pH 9 through ionization of the phenolic group.Verwenden
salicylamide is an analgesic, fungicide, and anti-inflammatory ingredient used to soothe the skin. It is an aromatic amide.Definition
ChEBI: The simplest member of the class of salicylamides derived from salicylic acid.Allgemeine Beschreibung
Salicylamide, o-hydroxybenzamide, is a derivative of salicylicacid that is fairly stable to heat, light, and moisture. Itreportedly exerts a moderately quicker and deeper analgesiceffect than aspirin because of quicker CNS penetration. Its metabolismdiffers from aspirin, because it is not metabolized tosalicylic acid but rather excreted exclusively as the ether glucuronideor sulfate. Thus, as a result of lack of contributionfrom salicylic acid, it has a lower analgesic and antipyretic efficacythan that of aspirin. However, it can be used in place ofsalicylates for patients with a demonstrated sensitivity to salicylates.It is also excreted much more rapidly than other salicylates,which accounts for its lower toxicity. It is available inseveral nonprescription products, in combination with acetaminophenand phenyltoloxamine (e.g., Rid-A Pain compound,Cetazone T, Dolorex, Ed-Flex, Lobac) or with aspirin,acetaminophen, and caffeine (e.g., Saleto, BC Powder).Air & Water Reaktionen
Salicylamide darkens on exposure to air. . Insoluble in water.Reaktivit?t anzeigen
Salicylamide is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). Salicylamide may be sensitive to prolonged exposure to light.Brandgefahr
Flash point data for Salicylamide are not available; however, it is probably combustible.Clinical Use
Whereas salicylamide is reported to be as effective as aspirin as an analgetic/antipyretic and is effective in relieving pain associated with arthritic conditions, it does not appear to possess useful anti-inflammatory activity. Thus, indications for the treatment of arthritic disease states are unwarranted, and its use is restricted to the relief of minor aches and pain at a dosage of 325 to 650 mg three or four times per day. Its effects in humans are not reliable, however, and its use is not widely recommended.l?uterung methode
Crystallise the amide from water or repeatedly from CHCl3 [Nishiya et al. J Am Chem Soc 108 3880 1986]. [Beilstein 10 IV 169.] The anilide [87-17-2] M 213.2, m 135o crystallises from H2O. [Beilstein 12 H 500, 12 I 268, 12 II 256, 12 944.]2-Hydroxybenzamid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-Hydroxybenzamid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 647)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
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Hebei Chuanghai Biotechnology Co., Ltd | +86-15531157085 +86-15531157085 |
abby@chuanghaibio.com | China | 8805 | 58 |
Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 |
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deasea125996@gmail.com | China | 2472 | 58 |
Anhui Ruihan Technology Co., Ltd | +8617756083858 |
daisy@anhuiruihan.com | China | 973 | 58 |
airuikechemical co., ltd. | +86-18353166132 +86-18353166132 |
sales02@airuikechemical.com | China | 983 | 58 |
Hebei Saisier Technology Co., LTD | +86-18400010335 +86-18034520335 |
admin@hbsaisier.cn | China | 1015 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 |
admin@zlchemi.com | China | 3692 | 58 |
Hebei Longbang Technology Co., LTD | +86-18633929156 +86-18633929156 |
admin@hblongbang.com | China | 972 | 58 |
65-45-2(2-Hydroxybenzamid)Verwandte Suche:
Phenoxybenzaminhydrochlorid
Natriumsalicylat
2-Acetoxybenzoylchlorid
Trimethoprim
Salicylaldehyd
4-Fluorbenzylamin
Salicylohydrazid
α-Hydroxy-o-tolyl-β-D-glucopyranosid
Ethenzamid
Salicylanilid
Sodium 4-aminosalicylate dihydrate
4-Amino-6-chlorbenzol-1,3-di(sulfonylchlorid)
2-Amino-5-chlorbenzolsulfonsure
Hydrochlorothiazid
Chlorothiazid
4-Amino-6-chlorbenzol-1,3-disulfonamid
Salicyls?ure
2-Hydroxyethylsalicylat
- Salicylamide o-Hydroxybenzamide Salamide
- Deferasirox Benzamide Impurity
- Salicylamide puriss., >=99.0% (T)
- O-HYDROXYBENZAMIDE
- SALICYLAMIDE
- 2-Carbamoylphenol
- 2-hydroxy-benzamid
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- SALICYLAMIDE, MATRIX SUBSTANCE FOR MALDI -MS
- SALICYLAMIDE, EXTRA PURE, USP
- Salicylamide NF, Granular