| Identification | Back Directory | [Name]
bromoacetaldehyde | [CAS]
17157-48-1 | [Synonyms]
2-BROMOACETALDEHYDE
Acetaldehyde, bromo-(6CI,7CI,8CI,9CI)
bromoacetaldehyde ISO 9001：2015 REACH
Bromoacetaldehyde
DISCONTINUED, offer stable form B678880 | [Molecular Formula]
C2H3BrO | [MDL Number]
MFCD01733508 | [MOL File]
17157-48-1.mol | [Molecular Weight]
122.95 |
| Hazard Information | Back Directory | [Uses]
Bromoacetaldehyde can be used as an intermediate in pharmaceutical and chemical synthesis, mainly in laboratory research and development and chemical production processes. | [Definition]
ChEBI:2-Bromoacetaldehyde is an organobromine compound. | [Synthesis]
Preparation of Bromoacetaldehyde:1,4-dibromo-trans-2-butene(10g, 0.046 mol) was dissolved in dry CH2CI2 (100 ml) and cooled to -780℃ and ozone gas was bubbled until the blue color persisted (~30 min). A nitrogen stream was passed through the solution until the blue color disappeared, giving colorless solution. Triphenyl phosphine (12.9g, 0.046 mol) was added portion wise over a period EPO of 1 hr. The reaction mixture was brought to 0℃ and kept in the refrigerator for 15 hrs. The solvent (CH2CI2) was removed from the reaction mixture (without applying vacuum) and the thick residue was distilled at 400℃ under vacuum (1mm Hg), maintaining the temperature of the receiving flask at -780℃. (during distillation, special care was taken to maintain a cold water circulation (~0°C to - 50℃)). The bromoacetaldehyde(2.8g, yield = 50%) was obtained as a light yellow liquid.
 |
|
|