Indol-1-yl-acetic acid synthesis
- Product Name:Indol-1-yl-acetic acid
- CAS Number:24297-59-4
- Molecular formula:C10H9NO2
- Molecular Weight:175.18
120-72-9
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Yield: 92%
Reaction Conditions:
with sodium hydroxide;tetrabutylammomium bromide in water;benzene
Steps:
1 (1H-Indol-1-yl)acetic Acid
EXAMPLE 1 (1H-Indol-1-yl)acetic Acid To a solution of ethyl 2-bromoacetate (25 g, 0.15 mole) and indole (11.7 g, 0.1 mole) in 100 ml of benzene is added a solution of sodium hydroxide (25 g, 0.626 mole) in 50 ml of water. To the obtained mixture is added tetra-n-butylammonium bromide (1.6 g, 0.5 mmole). The mixture is stirred at 25° C. for 16 hours. The aqueous phase is acidified to pH 3. The organic phase is separated, dried and evaporated to give the title compound in 92% yield. NMR (DMSO-D6) ppm (δ) 5.05 (s,2); 6.50 (d, 1), 6.9- 7.8 (m, 5).
References:
Yeda Research and Development Co. Ltd. US4139703, 1979, A
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1000210-73-0
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24297-59-4
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33140-80-6
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24297-59-4
119 suppliers
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120-72-9
646 suppliers
$6.00/25g
24297-59-4
119 suppliers
$5.00/250mg