Furan-2-carbonyl chloride, tetrahydro- synthesis
- Product Name:Furan-2-carbonyl chloride, tetrahydro-
- CAS Number:52449-98-6
- Molecular formula:C5H7ClO2
- Molecular Weight:134.56
16874-33-2
299 suppliers
$6.00/5g
52449-98-6
43 suppliers
$33.00/100mg
Yield: 99%
Reaction Conditions:
with oxalyl dichloride;N,N-dimethyl-formamide in dichloromethane at 20; for 0.5 h;
Steps:
83.a
To a solution of tetrahydro-2-furancarboxylic acid (1 g, 8.61 mmol) in Dichloromethane (DCM) (17.22 ml) was added oxalyl chloride (3.02 ml, 34.4 mmol), followed by 2 drops of DMF. The mixture was stirred at room temperature for 30 min, then excess oxalyl chloride and dichloromethane were removed in vacuo to provide crude tetrahydro-2- furancarbonyl chloride. (1.15 g, 99%).
References:
GLAXOSMITHKLINE LLC;LIN, Hong;LUENGO, Juan, I.;RIVERO, Ralph, A.;SCHULZ, Mark, James;XIE, Ren;ZENG, Jin WO2010/135504, 2010, A1 Location in patent:Page/Page column 75-76
87392-05-0
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$14.00/1G
52449-98-6
43 suppliers
$33.00/100mg
16874-33-2
299 suppliers
$6.00/5g
79-37-8
483 suppliers
$17.67/10gm:
52449-98-6
43 suppliers
$33.00/100mg
97-99-4
410 suppliers
$14.00/5g
52449-98-6
43 suppliers
$33.00/100mg
88-14-2
505 suppliers
$5.00/10g
52449-98-6
43 suppliers
$33.00/100mg