Tetrahydro-4-pyranol synthesis
- Product Name:Tetrahydro-4-pyranol
- CAS Number:2081-44-9
- Molecular formula:C5H10O2
- Molecular Weight:102.13
29943-42-8
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2081-44-9
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Yield:2081-44-9 99%
Reaction Conditions:
Stage #1: dihydro-2H-pyran-4(3H)-onewith lithium aluminium hydride in tetrahydrofuran at 0; for 0.5 h;
Stage #2: with sodium hydroxide in tetrahydrofuran;lithium hydroxide monohydrate;
Steps:
8.1
To a solution of 8a (5.Og, 50mmol) in THF (25mL) cooled to O0C, was added a suspension Of LiAlH4 (3.8g, O.lmol) in THF (5OmL) slowly. The resulting mixture was stirred at O0C for 30min, then was added water (3.8mL), followed by aqueous 15% NaOH (3.8mL) and water (1 1.4mL). The mixture was filtered and the solid was washed with ethyl ester (70mLχ2). The combined filtrate was evaporated to afford 8b (5.09g, 99%).
References:
WO2008/88881,2008,A1 Location in patent:Page/Page column 39
67-56-1
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187737-37-7
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1120-97-4
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2081-44-9
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107-88-0
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115-10-6
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542-05-2
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2081-44-9
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108-97-4
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2081-44-9
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72548-31-3
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2081-44-9
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