5-METHYLINDOLE-3-CARBOXYLIC ACID METHYL ESTER synthesis
- Product Name:5-METHYLINDOLE-3-CARBOXYLIC ACID METHYL ESTER
- CAS Number:227960-12-5
- Molecular formula:C11H11NO2
- Molecular Weight:189.21
67-56-1
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10242-02-1
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$8.00/100mg
227960-12-5
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$25.00/100mg
Yield: 90%
Reaction Conditions:
with thionyl chloride at 0 - 20; for 9 h;Reflux;
Steps:
For the derivativation of indole-3-carboxylic acids 2b and 2k
General procedure: Following the above procedure, the crude reaction mixture was diluted with MeOH and cooled to 0°C. Then SOCl2 (36 μL, 0.5 mmol) was added and stirred for 3 h at room temperature. Additional MeOH was added and the reaction mixture was heated to reflux for 6 h. The resulting mixture was quenched with H2O and extracted with EtOAc (3x). The combined organic layers were dried over MgSO4 and concentrated under reduced pressure. The resulting crude residue was purified by preparative TLC (hexane:EtOAc = 7:3) to afford the desired products 5a-b.
References:
Yoo, Woo-Jin;Nguyen, Thanh V. Q.;Guiteras Capdevila, Montse;Kobayashi, Shu [Heterocycles,2015,vol. 90,# 2,p. 1196 - 1204]
124-41-4
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$12.00/25g
227960-12-5
86 suppliers
$25.00/100mg
614-96-0
317 suppliers
$19.00/1g
227960-12-5
86 suppliers
$25.00/100mg
10242-02-1
86 suppliers
$8.00/100mg
227960-12-5
86 suppliers
$25.00/100mg