5-Bromo-2-methoxypyridine synthesis
- Product Name:5-Bromo-2-methoxypyridine
- CAS Number:13472-85-0
- Molecular formula:C6H6BrNO
- Molecular Weight:188.02
Yield:13472-85-0 98%
Reaction Conditions:
with sodium hydroxide for 5 h;Reflux;
Steps:
3.1, 1Br Example 3
(1) In a 500 ml reaction flask, 47 g of 2,5-dibromopyridine,8 g of solid sodium hydroxide and 200 ml of methanol,Stirring began to heat up to reflux, the reaction time was 5 hours,Stop the reaction, steamed most of the methanol, cooled, add 100 ml of water,Extract once with dichloromethane, remove methylene chloride to give the crude product,The crude product was distilled under reduced pressure to give 2-methoxy-5-bromopyridine,The yield is 98%.
References:
Huaihua Jinxin New Materials Co., Ltd.;Wang Youming CN106905229, 2017, A Location in patent:Paragraph 0026; 0027
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