午夜插插,噜噜噜影院,啪啪伊人网,欧美熟夫,景甜吻戏视频,男人强操性感蕾丝美女视频在线网站,日本美女跳舞视频

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 4-TOLYLISOCYANIDE
7175-47-5

4-TOLYLISOCYANIDE synthesis

11synthesis methods
To a flask containing 5.4 gm (0.05 mole) of p-toluidine in 100 ml of dry 1,2-dimethoxyethane is added 28 gm (0.15 mole) of sodium trichloroacetate. The reaction is slightly exothermic. The reaction mixture is refluxed for ? hr, whereupon carbon dioxide is copiously evolved. The reaction mixture is filtered, the solid (10 gm) is washed with ether, and the combined reddish black filtrate concentrated. The residue is extracted with ether, washed with water, dried, and concentrated to afford a red-black oil, which, upon distillation, gives 2.5 gm (43%), b.p. 38°C (1 mm Hg), m.p. 19-20°C of a yellow liquid, IR, 4.69 μ (—NC).
Preparation ofp-Tolyl Isonitrile
-

Yield:7175-47-5 95%

Reaction Conditions:

with diisopropylamine;trichlorophosphate in dichloromethane at 0 - 20;Inert atmosphere;

Steps:

Representative procedure for the synthesis of isonitriles: Compound (2g)

To a stirring 0 °C mixture of DIPA (2.7 equiv, 3.9 mL) and N-(3-bromophenyl)formamide (2.06 g) in DCM (0.9 M), as added POCl3 (1.1 equiv, 1.06 mL) dropwise under argon. After 5 min at 0°C and 15 min at room temperature, 10 mL water was added and mixed vigorously until the organic layer became clear. The organic layer was separated, loaded onto a short silica gel flash column, and eluted with 4:1 hexanes:ethyl acetate to give 1.53 g (81%) of a foul-smelling yellow liquid which became dark green after drying in vacuo 10 min.

References:

Polisar, Jason G.;Li, Ling;Norton, Jack R. [Tetrahedron Letters,2011,vol. 52,# 23,p. 2933 - 2934] Location in patent:supporting information; experimental part

4-TOLYLISOCYANIDE Related Search: