7H-Pyrazolo[4,3-d]pyrimidin-7-one, 1,4-dihydro-1-methyl- (9CI) synthesis
- Product Name:7H-Pyrazolo[4,3-d]pyrimidin-7-one, 1,4-dihydro-1-methyl- (9CI)
- CAS Number:314021-93-7
- Molecular formula:C6H6N4O
- Molecular Weight:150.14
923283-54-9
41 suppliers
$65.00/100mg
3473-63-0
499 suppliers
$5.00/25g
314021-93-7
45 suppliers
$305.00/250mg
Yield:314021-93-7 94%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in butan-1-ol at 110; for 1 h;
Steps:
4
Compound 8: To a solution of 7 (0.92 g, 5.9 mmol) in 5 mL of Hunig's base and 5 mL of n-butanol was added formamidine acetate (0.68 g, 6.5 mmol). The reaction mixture was heated and stirred at 110° C. for 1 hour. After cooling to room temperature, the white precipitate was collected by filtration and washed with diethyl ether. The resulting white precipitate was dried under reduced pressure to afford 8 (0.83 g, 94%). 1H NMR (d6-DMSO) δ 4.33 (s, 3H) 8.50 (s, 1H) 8.80 (s, 1H); ES (+) MS m/e=151 (M+1).
References:
US2007/27166,2007,A1 Location in patent:Page/Page column 80
1260659-38-8
10 suppliers
inquiry
60100-09-6
0 suppliers
inquiry
314021-93-7
45 suppliers
$305.00/250mg