1-Methyl-1H-imidazole-2-carboxylic acid synthesis
- Product Name:1-Methyl-1H-imidazole-2-carboxylic acid
- CAS Number:20485-43-2
- Molecular formula:C5H6N2O2
- Molecular Weight:126.11
13750-81-7
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20485-43-2
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$19.00/250mg
Yield:20485-43-2 100%
Reaction Conditions:
with dihydrogen peroxide in water at 20; for 72 h;
Steps:
MeIm2COOH (1c)
First, 1-methylimidazole-2-carboxaldehyde was prepared according to the literature procedure[23]. The synthesis procedure then followed that of Im2COOH (1b) above and the yield was also quantitative after the removal of water under high vacuum (no washing with diethylether/water was necessary). Note: heating causes decarboxylation. Yield: 100%. Mp=99-101°C. δH (400MHz, D2O): 7.42, 7.39 (2H, s, Im-H) and 4.08ppm (3H, s, NCH3); δC (400MHz, D2O): 158.67, 139.68, 125.83, 118.46, 36.73ppm. IR ν (KBr): 3347(m) 3119(m), 2663(w), 1641(s), 1683(m), 1507(s), 1449(m), 1388(s), 1338(s), 1285(s), 1173(m), 1123(s), 961(m) 910(m), 776(s), 685(s) cm-1. Anal. Calc. for C5H8N2O3 (144.12); C, 41.67; H, 5.59; N, 19.44%. Found: C, 41.28; H, 5.23; N, 19.12%.
References:
Gundhla, Isaac Z.;Walmsley, Ryan S.;Ugirinema, Vital;Mnonopi, Nandipha O.;Hosten, Eric;Betz, Richard;Frost, Carminita L.;Tshentu, Zenixole R. [Journal of Inorganic Biochemistry,2015,vol. 145,p. 11 - 18]
30148-21-1
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20485-43-2
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$19.00/250mg
541-41-3
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20485-43-2
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616-47-7
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124-38-9
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20485-43-2
184 suppliers
$19.00/250mg