3-Formyl-4-hydroxybenzonitrile synthesis
- Product Name:3-Formyl-4-hydroxybenzonitrile
- CAS Number:74901-29-4
- Molecular formula:C8H5NO2
- Molecular Weight:147.13
21962-53-8
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Yield:74901-29-4 86%
Reaction Conditions:
with lithium chloride in DMF (N,N-dimethyl-formamide)
Steps:
25.B
B. 2-Hydroxy-5-cyanobenzaldehyde 31.08 g of compound obtained in the preceding step and 24.52 g of lithium chloride are introduced into 500 ml of N,N-dimethylformamide. The mixture is brought to reflux for 2 hours and the solvent is evaporated off. The residue is taken up in a potassium acid sulfate solution and extraction is carried out with ethyl acetate. Washing is then carried out with water and a saturated sodium chloride solution. In this way, 24.5 g of desired compound are obtained. Yield: 86%
References:
Assens, Jean-Louis;Bernhart, Claude;Cabanel-Haudricourt, Frederique;Nisato, Dino US2004/10011, 2004, A1 Location in patent:Page/Page column 26
767-00-0
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141-78-6
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50-00-0
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767-00-0
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161196-99-2
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