ChemicalBook CAS DataBase List Formyl acetate

Formyl acetate synthesis

9synthesis methods

Product Name:Formyl acetate
CAS Number:2258-42-6
Molecular formula:C3H4O3
Molecular Weight:88.06

Preparative Methods of Formyl acetate: acetic formic anhydride is not comercially available. The easiest method of preparation is by the reaction of sodium formate and Acetyl Chloride in dry ether as reported by Krimen. Alternatively, Ketene and Formic Acid form the title compound at room temperature or below. Acetic formic anhydride can be prepared rapidly in situ by stirring formic acid, acetyl chloride, and Triethylamine in THF at -70 °C for 10 min. AFA is found in a mixture of formic acid (excess) with Acetic Anhydride. The mixture is more accurately described as formic acid-acetic anhydride mixture (FAM) and is also used as a formylating agent. Purification: by fractional distillation at low pressure.

64-18-6 Synthesis

64-18-6
1087 suppliers
$22.12/250ML

108-24-7
5 suppliers
$14.00/250ML

2258-42-6
45 suppliers
inquiry

Yield:2258-42-6 100%

Reaction Conditions:

at 60; for 1 h;Inert atmosphere;

Steps:

17.1
Under the protection of nitrogen, 17a (4mL, 0.11mmol) and acetic anhydride (2.5mL, 0.03mmol) were mixed, and the temperature was raised to 60°C and stirred for 1 hour. After cooling the reaction liquid, a crude product of 17b (6.5 mL) was obtained, and the yield was 100%.

References:

CN112279853, 2021, A Location in patent:Paragraph 0252-0253; 0254-0255

FullText

75-36-5 Synthesis