3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one synthesis
- Product Name:3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one
- CAS Number:881386-01-2
- Molecular formula:C11H10Cl2N2O3
- Molecular Weight:289.11
38560-30-4
177 suppliers
$11.00/250mg
881386-01-2
145 suppliers
inquiry
Yield:881386-01-2 94.9%
Reaction Conditions:
with phosphorus(V) chloride in chlorobenzene at 55; for 5 h;
Steps:
1 Synthesis of 3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one
Compound II (40 g, 0.18 mol) was added to a 1000 mL eggplant-Chlorobenzene (400 ml),Phosphorus pentachloride (132.4 g, 0.64 mol) was added portionwise with stirring,After the addition warmed to 55 reaction 5h.The reaction solution was cooled to room temperature,Poured into 1000mL ice water,Separate the lower, and then extracted with dichloromethane 3 × 200mL,The combined organic phases were washed twice with 2 × 200 mL of water,400mL saturated brine was washed once,Dried over anhydrous sodium sulfate,Dichloromethane evaporated to give the product,Light yellow solid, 49.4 g, m.p.115-117°C, Yield 94.9%.
References:
CN107400131,2017,A Location in patent:Paragraph 0026; 0031; 0036-0038
1575-61-7
361 suppliers
$14.00/1g
881386-01-2
145 suppliers
inquiry
100-01-6
23 suppliers
$11.19/25G
881386-01-2
145 suppliers
inquiry
1039914-85-6
58 suppliers
inquiry
881386-01-2
145 suppliers
inquiry
4509-90-4
235 suppliers
$15.00/1g
881386-01-2
145 suppliers
inquiry