ChemicalBook CAS DataBase List 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester

1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester synthesis

6synthesis methods

Product Name:1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester
CAS Number:503614-91-3
Molecular formula:C27H28N4O5
Molecular Weight:488.54

545445-44-1 Synthesis

3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one

545445-44-1
456 suppliers
$7.00/1g

27143-07-3 Synthesis

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate

27143-07-3
467 suppliers
$6.00/250mg

1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester

503614-91-3
299 suppliers
$8.00/250mg

Yield:503614-91-3 89.9%

Reaction Conditions:

with triethylamine;potassium iodide in ethyl acetate for 24 h;Reflux;

Steps:

2
(14 mmol) of the compound of the formula (IV) and 4. 0 g (16 mmol)The compound of structure (V) was added to 150 mL of ethyl acetate,0.35 g (2 mmol) of KI, 6.8 ml (49 mmol) of triethylamine was added and refluxed for 24 h, Cooled to 0°C degrees, dropping 4M dilute hydrochloric acid 20mL, stirring at room temperature 2h, filtration, a small amount of cold ethyl acetate washing, water hit the public, about 50 ° C blast drying,To obtain crude product 6. 5g, yield 94. 6%, and then recrystallized from ethyl acetate, To obtain 5.8 g of a solid, powdery product,The yield was 89% and the purity was 99.8%.

References:

Jiangsu Kanion Pharmaceutical Co . Ltd;Xiao, Wei;Zhang, Wei;Chang, Xinglong;Li, Yingguang;Wang, Zhenzhong;Guo, Qingming CN105254630, 2016, A Location in patent:Paragraph 0056; 0057; 0058

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675-20-7 Synthesis