2-Methylmercaptobenzothiazole synthesis
- Product Name:2-Methylmercaptobenzothiazole
- CAS Number:615-22-5
- Molecular formula:C8H7NS2
- Molecular Weight:181.28
95-16-9
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615-22-5
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Yield:615-22-5 79%
Reaction Conditions:
with carbonylhydridetris(triphenylphosphine)rhodium(I);1,3-bis(dicyclohexylphosphine)propane in 1,2-dichloro-benzene for 3 h;Inert atmosphere;Reflux;
Steps:
2-(methylthio)-4-phenylthiazole 3a:
1,3-bis(dicyclohexylphosphino)propane (dcypp: 20.0 mol%, 21.9mg) was dissolved in o-dichlorobenzene (1.0 mL) in a two-necked flask equipped under argon atmosphere. Then, RhH(CO)(PPh3)3 (10.0 mol%, 23.0 mg), 4-phenylthiazole 1a (0.25 mmol, 40.3 mg)and 2-methylthiothiazole 5 (0.75 mmol, 78 L) were added to the solution, and the mixture was heated at reflux for 3 h. Then, the solvent was removed under reduced pressure, and the residue was purified byflash columm chromatography on silica gel giving 2-(methylthio)-4-phenylthiazole 3a (38.5 mg, 74%). 3a11
References:
Arisawa, Mieko;Nihei, Yuri;Yamaguchi, Masahiko [Heterocycles,2015,vol. 90,# 2,p. 939 - 949]
3507-54-8
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615-22-5
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