2-METHYL-4'-(TRIFLUOROMETHYL)-1,1'-BIPHENYL synthesis
- Product Name:2-METHYL-4'-(TRIFLUOROMETHYL)-1,1'-BIPHENYL
- CAS Number:167021-49-0
- Molecular formula:C14H11F3
- Molecular Weight:236.23
Yield:167021-49-0 99%
Reaction Conditions:
with potassium phosphate;[5-(3-butylbenzimidazol-2-yliden-1-yl)-25,26,27,28-tetrapropyloxy calix[4]arene] (pyridine) palladium(II) dibromide in 1,4-dioxane at 100; for 24 h;Inert atmosphere;
Steps:
4.2.6 General procedure for Pd-catalysed Suzuki-Miyaura coupling
General procedure: In air, potassium phosphate (3mmol, 0.636g), catalyst 1 (0.08mol%, 0.0009g) and arylboronic acid (2mmol) were weighed into a 50mL glass vial that was sealed with a septum and purged with N2 (3×). Dioxane (1mL) was then injected via syringe followed by the aryl bromide (1mmol) (if liquid). If the aryl bromide was a solid, it was introduced into the vial prior to purging with N2. At this time, the reaction stirred for 24h at 100°C. The reaction mixture was concentrated in vacuo and directly purified via silica gel flash chromatography.
References:
Ren, Hui;Xu, Yong;Jeanneau, Erwann;Bonnamour, Isabelle;Tu, Tao;Darbost, Ulrich [Tetrahedron,2014,vol. 70,# 17,p. 2829 - 2837]
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