(4'-TRIFLUOROMETHYL-BIPHENYL-2-YL)-METHANOL synthesis

6synthesis methods

Product Name:(4'-TRIFLUOROMETHYL-BIPHENYL-2-YL)-METHANOL
CAS Number:773871-77-5
Molecular formula:C14H11F3O
Molecular Weight:252.23

5159-41-1 Synthesis

5159-41-1
219 suppliers
$8.00/5g

128796-39-4 Synthesis

128796-39-4
428 suppliers
$10.00/5g

(4'-TRIFLUOROMETHYL-BIPHENYL-2-YL)-METHANOL

773871-77-5
12 suppliers
$370.00/250mg

Yield:773871-77-5 99%

Reaction Conditions:

with C₂₂H₂₄Cl₂N₆O₂Pd₂;potassium carbonate in ethanol;water; for 4 h;Catalytic behavior;Reflux;Suzuki-Miyaura Coupling;

Steps:

General Procedure for the Suzuki-Miyaura cross-coupling reaction:

General procedure: In a 10 mL glass tube containing a Teflon-coated stir bar was placed p-bromobenzaldehyde 2e (0.05 g, 0.27 mmol, 1 equiv), phenylboronic acid 1a (0.05 g, 0.40 mmol, 1.5 equiv), 2M K₂CO₃ (0.33 mL, 0.67 mmol, 2.5 equiv), 4-AAP-Pd(II) (0.28 mg, 0.3 mol % Pd) and EtOH (2 mL). The mixture was stirred at reflux for 4 h. After cooling, the mixture was diluted with ether Et₂O (5 mL), washed with sat. aq. NaHCO₃ (3 mL), brine (3 mL) and dried over Na₂SO₄. Evaporation of the solvent and purification of the residue over a silica gel column (Hex: AcOEt 90:10), furnished the biphenyl 3q.

References:

Contreras-Celedn, Claudia A.;Mendoza-Rayo, Daro;Rincn-Medina, Jos A.;Chacn-Garca, Luis [Beilstein Journal of Organic Chemistry,2014,vol. 10,p. 2821 - 2826] Location in patent:supporting information

84392-17-6 Synthesis