2-(Chloromethyl)thiophene synthesis
- Product Name:2-(Chloromethyl)thiophene
- CAS Number:765-50-4
- Molecular formula:C5H5ClS
- Molecular Weight:132.61
Yield:765-50-4 203 mg
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in dichloromethane at 0 - 20;
Steps:
2-(Chloromethyl)thiophene
A solution ofthiophen-2-ylmethanol (200 mg, 1.75 mmol), diisopropylethylamine (DIEA,453 mg, 612 )lL, 3.5 mmol) in DCM (5 mL) was cooled to 0 °C, MsCl (163 )lL, 2.1 mmol) wasadded and the mixture warmed to RT. After 2 h H20 and DCM were added, the organic layerseparated and washed with sat. NH4Cl, H20, sat. NaHC03, dried with MgS04 and concentrated togive the title compound (203 mg, light brown oil) which was used without purification MS m/z25 133 (MH+).
References:
F. HOFFMANN-LA ROCHE AG;HOFFMANN-LA ROCHE INC.;HAN, Xiaochun;LOU, Yan;MICHOUD, Christophe;MISCHKE, Steven Gregory;REMISZEWSKI, Stacy;RUPERT, Kenneth Carey WO2014/9495, 2014, A1 Location in patent:Page/Page column 44
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