ChemicalBook CAS DataBase List 2-Thiophenemethanol

2-Thiophenemethanol synthesis

9synthesis methods

Product Name:2-Thiophenemethanol
CAS Number:636-72-6
Molecular formula:C5H6OS
Molecular Weight:114.17

79387-71-6 Synthesis

79387-71-6
140 suppliers
$24.00/1g

636-72-6
255 suppliers
$6.00/5g

Yield:636-72-6 85%

Reaction Conditions:

with (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;sodium tetrahydroborate;N,N,N,N,-tetramethylethylenediamine in tetrahydrofuran at 25; for 10 h;Inert atmosphere;

Steps:

General procedure for the hydrodehalogenation of halogenated heterocycles
General procedure: PdCl₂(dppf), PdCl₂(tbpf) and (A.^caPhos)PdCl₂. A mixture of the halogenated heterocycle (0.66 mmol) in anhydrous THF (13.2 mL) was degassed by bubbling argon for few minutes. Then, PdCl₂(dppf) (27.0 mg, 0.033 mmol, 5.0 mol%), TMEDA (0.130 g, 1.12 mmol, 1.7 equiv) and finally NaBH₄ (42.4 mg, 1.12 mmol, 1.7 equiv) were introduced in sequence. The mixture was stirred at room temperature under argon for the proper time and then worked up as described above.

References:

Chelucci, Giorgio;Figus, Susanna [Journal of Molecular Catalysis A: Chemical,2014,vol. 393,p. 191 - 209]

FullText

79757-77-0 Synthesis