2-BROMO-5-METHYL-4-NITROANISOLE synthesis
- Product Name:2-BROMO-5-METHYL-4-NITROANISOLE
- CAS Number:861076-28-0
- Molecular formula:C8H8BrNO3
- Molecular Weight:246.06
67-56-1
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224185-19-7
196 suppliers
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861076-28-0
66 suppliers
$79.00/250 mg
Yield: 87.8%
Reaction Conditions:
Stage #1:methanol with sodium at 0; for 0.5 h;
Stage #2:3-bromo-4-fluoro-6-methylnitrobenzene at 30; for 2 h;
Steps:
28
1-Bromo-2-methoxy-4-methyl-5-nitrobenzene Na (351 mg, 15.28 mmol) was added into CH3OH (20 mL) and the resulting mixture was stirred at 0 °C for 30 min. 1-Bromo-2-fluoro-4-methyl-5- nitrobenzene (3.25 g, 13.89 mmol) was added to the mixture and then stirred at 30 °C for 2 h. The solvent was removed and the residue was dissolved in H2O, extracted with ethyl acetate. The organic layer was washed with brine, dried over Na2SO4 and concentrated in vacuo. The residue was purified by column chromatography on silica gel (ethyl acetate/petroleum ether = 1:50) to yield the product as a white solid (3.0 g, 87.8% yield).
References:
ARAXES PHARMA LLC;LI, Liansheng;FENG, Jun;WU, Tao;REN, Pingda;LIU, Yi;LIU, Yuan;LONG, Yun, Oliver WO2015/54572, 2015, A1 Location in patent:Page/Page column 247
5367-32-8
180 suppliers
$10.00/5g
861076-28-0
66 suppliers
$79.00/250 mg
2581-34-2
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74-88-4
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$15.00/10g
1196875-90-7
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inquiry
861076-28-0
66 suppliers
$79.00/250 mg
5367-32-8
180 suppliers
$10.00/5g
1196875-90-7
7 suppliers
inquiry
861076-28-0
66 suppliers
$79.00/250 mg
67-56-1
773 suppliers
$7.29/5ml-f
124-41-4
714 suppliers
$12.00/25g
224185-19-7
196 suppliers
$7.00/1g
861076-28-0
66 suppliers
$79.00/250 mg