2-(4-PIPERIDYL)-2-PROPANOL synthesis
- Product Name:2-(4-PIPERIDYL)-2-PROPANOL
- CAS Number:22990-34-7
- Molecular formula:C8H17NO
- Molecular Weight:143.23
160809-39-2
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Yield: 100%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in methanol under 760.051 Torr;
Steps:
42-3 Production example 42-3; 4-(1-Hydroxy-1-methylethyl)piperidine
Benzyl 4-(1-hydroxy-1-methylethyl)piperidine-1-carboxylate (1.786 g, 6.44 mmol) synthesised in Production example 42-2 was dissolved in methanol (100 ml) under nitrogen atmosphere; 10% palladium on carbon (50% wet, 1.37 g) was added; the reaction system was purged with hydrogen at atmospheric pressure; and the reaction mixture was stirred overnight. After the reaction system was purged with nitrogen, the catalyst was filtered out, and washed with methanol; the solvent, together with the filtrate and the washing solution, was distilled off; and the residue was dried under reduced pressure to yield the title compound (922 mg, 6.44 mmol, quantitative) as pale gray crystals. 1H-NMR Spectrum (CDCl3) δ (ppm): 1.18 (6H, s), 1.26-1.42 (3H, m), 1.74-1.80 (2H, m), 2.57-2.64 (2H, m), 3.14-3.22 (2H, m), 3.48 (1H, s).
References:
Eisai Co., Ltd. EP1522540, 2005, A1 Location in patent:Page/Page column 64
299428-04-9
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