N-Boc-Piperidine-4-carboxylic acid methyl ester synthesis
- Product Name:N-Boc-Piperidine-4-carboxylic acid methyl ester
- CAS Number:124443-68-1
- Molecular formula:C12H21NO4
- Molecular Weight:243.3
2971-79-1
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24424-99-5
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$13.50/25G
124443-68-1
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$6.00/5g
Yield:124443-68-1 98%
Reaction Conditions:
with triethylamine in dichloromethane at 25; for 12 h;Product distribution / selectivity;
Steps:
A.2.1
Synthesis of 9-(Azetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane Trifluoroacetate (A4); Step-1: 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate; To a stirred solution of methyl isonipecotate (127.2 mmol, 1 eq) in dichloromethane (200 ml) were added di-tert-butyldicarbonate (190.8 mmol, 1.5 eq) and triethylamine (254.4 mmol, 2.0 eq). The reaction mixture was stirred for 12 h at 25° C. It was then diluted with dichloromethane (100 ml) and washed with water (50 ml) and brine (50 ml). The organic layer was separated, dried over Na2SO4, concentrated and employed in the next step without further purification. Yield: 98%
References:
US2010/113417,2010,A1 Location in patent:Page/Page column 36
67-56-1
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$9.00/25ml
84358-13-4
393 suppliers
$5.00/5g
124443-68-1
264 suppliers
$6.00/5g
67-56-1
774 suppliers
$9.00/25ml
498-94-2
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$5.00/10g
24424-99-5
859 suppliers
$13.50/25G
124443-68-1
264 suppliers
$6.00/5g
84358-13-4
393 suppliers
$5.00/5g
74-88-4
351 suppliers
$15.00/10g
124443-68-1
264 suppliers
$6.00/5g
84358-13-4
393 suppliers
$5.00/5g
18107-18-1
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$33.00/5g
124443-68-1
264 suppliers
$6.00/5g