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ChemicalBook CAS DataBase List 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol
147118-36-3

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol synthesis

10synthesis methods
-

Yield:147118-36-3 98%

Reaction Conditions:

with methanol;sodium tetrahydroborate in tetrahydrofuran at 5 - 25; for 2 h;

Steps:

2 Example 2
Compound IV (10 g) was added to a reaction flask, which was dissolved in tetrahydrofuran (60 mL) and methanol (20 mL), and the mixture was cooled to 5 to 10 ° C, and sodium borohydride (0.91 g) was added. Stir at 5 ° C for 2 hours and slowly warm to 25 ° C. The reaction was quenched by the addition of a saturated ammonium chloride solution and the pH was adjusted to 7-8. 50 mL of ethyl acetate was added, allowed to stand, and the layers were separated. The organic layer and the aqueous layer were separated, and then aqueous layer was extracted with ethyl acetate (60mL). The ethyl acetate extracts and organic layers were combined and washed sequentially with water (40 mL) and brine (aq. The organic layer was dried over anhydrous sodium sulfate.Concentration gave Compound V (9.8 g) in a yield of 98%.

References:

Nanjing Ouxin Pharmaceutical Co., Ltd.;Chen Benshun;Zhou Changyue CN108997324, 2018, A Location in patent:Paragraph 0024

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