(4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate synthesis
- Product Name:(4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
- CAS Number:125971-94-0
- Molecular formula:C14H23NO4
- Molecular Weight:269.34
773837-37-9
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Yield:125971-94-0 92.5%
Reaction Conditions:
with tetrabutylammonium bromide at 150;Temperature;Reagent/catalyst;
Steps:
1-7 Example 4
In a glass reactor equipped with a reflux condenser, compound 2 (27.9 g, 0.1 mol),Sodium cyanide (12.25g, 0.25mol), tetrabutylammonium bromide (0.002mol),Mix uniformly, heat up to 150°C, stir the reaction, and drop to room temperature after the reaction is completed.Add water and n-hexane to stir, separate the liquid, add n-hexane to extract twice, add hydrogen peroxide or sodium thiosulfate to the aqueous layer to sterilize the remaining sodium cyanide, combine the organic layers,Washed with saturated brine, dried over anhydrous sodium sulfate, filtered, concentrated, and distilled under reduced pressure to obtain compound 1.The product yield was 92.5% and the purity was 98.0%.
References:
CN114181188,2022,A Location in patent:Paragraph 0031-0045
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