ChemicalBook CAS DataBase List 1-(4-FLUORO-PHENYL)-PYRROLE-2,5-DIONE

1-(4-FLUORO-PHENYL)-PYRROLE-2,5-DIONE synthesis

4synthesis methods

Product Name:1-(4-FLUORO-PHENYL)-PYRROLE-2,5-DIONE
CAS Number:6633-22-3
Molecular formula:C10H6FNO2
Molecular Weight:191.16

108-31-6 Synthesis

108-31-6
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$13.47/50g

371-40-4 Synthesis

371-40-4
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$5.00/5G

6633-22-3
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$69.00/200mg

Yield:6633-22-3 95.5%

Reaction Conditions:

with sodium acetate;acetic acid at 20 - 85; for 6 h;

Steps:

Synthesis

HL was prepared by the two-steps process (Scheme 1). At first N-(4-fluorophenyl)maleimide was obtained in the following way. A mixture of 11.1 g (0.1 mol) of 4-fluoroaniline with 10.0 g (0.105 mol) of maleic anhydride, 8.2 g sodium acetate, and 50 mL acetic acid was stirred over 1 h at room temperature. Then the mixture was heated at 80-85C for 5 h. Upon following cooling down the flask content was poured onto ice. The colourless precipitate was filtered off and washed with water. Yield 18.3 g(95.5%), mp 147.5C [20].

References:

Ferenc;Sadowski;Tarasiuk;Cristóv?o;Osypiuk;Sarzyński [Russian Journal of General Chemistry,2017,vol. 87,# 11,p. 2719 - 2727][Zh. Obshch. Khim.,2017,vol. 87,# 11,p. 2719 - 2727,9]