
4-Fluoroaniline synthesis
- Product Name:4-Fluoroaniline
- CAS Number:371-40-4
- Molecular formula:C6H6FN
- Molecular Weight:111.12

350-46-9
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371-40-4
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$5.00/5G
Yield:371-40-4 100%
Reaction Conditions:
with 10% Pd/C;hydrogen in methanol at 20; for 3 h;
Steps:
2 4.2.2. 4-Fluoroaniline (4a)
To a solution of 4-fluoro-1-nitrobenzene (3a, 212 mL, 2.00 mmol)in MeOH (10 mL) was added 10% Pd/C (21 mg, 0.020 mmol). Thereaction mixture was stirred and bubbled with H2 at room temperaturefor 3 h. The solids were filtered off and washed with DCM(25 mL). The filtrate and DCM washing were combined andconcentrated under reduced pressure to give 4a as a clear yellow oil(222 mg, 100%).
References:
Teo, Theodosia;Yang, Yuchao;Yu, Mingfeng;Basnet, Sunita K.C.;Gillam, Todd;Hou, Jinqiang;Schmid, Raffaella M.;Kumarasiri, Malika;Diab, Sarah;Albrecht, Hugo;Sykes, Matthew J.;Wang, Shudong [European Journal of Medicinal Chemistry,2015,vol. 103,p. 539 - 550]

460-00-4
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371-40-4
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352-34-1
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371-40-4
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3296-02-4
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371-40-4
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1765-93-1
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371-40-4
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$5.00/5G