1-(4-CHLOROBENZYL)-1H-INDOLE-2-CARBOXYLIC ACID synthesis

6synthesis methods

Product Name:1-(4-CHLOROBENZYL)-1H-INDOLE-2-CARBOXYLIC ACID
CAS Number:220677-67-8
Molecular formula:C16H12ClNO2
Molecular Weight:285.73

ethyl 1-(4-chlorobenzyl)-1H-indole-2-carboxylate

199604-34-7
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1-(4-CHLOROBENZYL)-1H-INDOLE-2-CARBOXYLIC ACID

220677-67-8
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$184.00/500mg

Yield:220677-67-8 99%

Reaction Conditions:

with potassium hydroxide in ethanol at 20; for 24 h;

Steps:

4.2.3 Alkaline hydrolysis

General procedure: To a solution of ethyl ester (2mmol) in ethanol was added 1M KOH (4mL) and the mixture stirred for 24h at room temperature. Upon completion of the reaction which was monitored by TLC, the ethanol was evaporated from the mixture and the remaining water phase acidified with 1M HCl to pH ～3. The obtained precipitate was filtered off and dried at 75°C in an oven to afford compounds.

References:

Ke?ek Ple?ec, Kaja;Urban?i?, Dunja;Gobec, Martina;Peko?ak, Aleksandra;Toma?i?, Tihomir;Anderluh, Marko;Mlinari?-Ra??an, Irena;Jakopin, ?iga [Bioorganic and Medicinal Chemistry,2016,vol. 24,# 21,p. 5221 - 5234]