Yield:-

Reaction Conditions:

with hydrogenchloride in water;ethyl acetate at 20; for 3 h;

Steps:

2 Step 2: Synthesis of ethyl [1,4'-bipiperidine]-4-carboxylate

To a solution of HCl in EtOAc (200 mL) was added 1'-tert-butyl 4-ethyl [1,4'- bipiperidine]-1',4-dicarboxylate (20 g, 58.74 mmol, 1.0 equiv). The mixture was stirred at room temperature for 3 h. The mixture was then concentrated under reduced pressure to afford the desired crude product as a white solid (15 g, HCl salt).

References:

WO2019/212990,2019,A1 Location in patent:Paragraph 00695