[1,4']BIPIPERIDINYL-3-CARBOXYLIC ACID ETHYL ESTER synthesis
- Product Name:[1,4']BIPIPERIDINYL-3-CARBOXYLIC ACID ETHYL ESTER
- CAS Number:340962-71-2
- Molecular formula:C13H24N2O2
- Molecular Weight:240.34
![1,4']Bipiperidinyl-3,1'-dicarboxylic acid 1'-tert-butyl ester 3-ethyl ester](/CAS/20210111/GIF/433981-21-6.gif)
433981-21-6
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340962-71-2
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Yield:340962-71-2 97%
Reaction Conditions:
with hydrogenchloride;water in dichloromethane; for 18 h;
Steps:
18.D
D. [1,4']Bipiperidinyl-3-carboxylic acid ethyl ester. To a solution of [1,4']bipiperidinyl-3,1'-dicarboxylic acid 1'-tert-butyl ester 3-ethyl ester (6.9 g, 20.3 mmol) in CH2Cl2 (100 mL) was added 25.4 mL 4 N HCl (101 mmol). The resulting solution was stirred for 18 h. The reaction mixture was concentrated to yield a solid. The solid was tritrated with Et2O and collected by filtration to yield 4.6 g of the desired product (97%). MS (ESI): mass calculated for C16H28N2O4, 240.2; m/z found, 241.2 [M+H]+. 1H NMR (400 MHz, CDCl3): 4.18 (q, J=7.1, 2H), 3.77-3.58 (m, 6H), 3.37-3.00 (m, 2H), 2.45-2.42 (m, 4H), 2.23-1.90 (m, 6H), 1.76-1.58 (m, 1H), 1.27 (t, J=7.1, 3H).
References:
US2006/223792,2006,A1 Location in patent:Page/Page column 29
340962-86-9
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3612-20-2
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340962-71-2
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71962-74-8
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340962-71-2
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