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ChemicalBook >> CAS DataBase List >> VU0483605

VU0483605

VU0483605 price.
  • $49 - $942
  • Product name: VU0483605
  • CAS: 1623101-11-0
  • MF: C20H10Cl3N3O3
  • MW: 446.67
  • EINECS:
  • MDL Number:MFCD29770792
  • Synonyms:VU0483605;2-Chloro-N-[3-chloro-4-(4-chloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)phenyl]nicotinamide;3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide;3-Chloro-N-[3-chloro-4-(4-chloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-2-pyridinecarboxamide;2-Pyridinecarboxamide, 3-chloro-N-[3-chloro-4-(4-chloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-;3-chloro-N-[3-chloro-4-(4-chloro-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)phenyl]pyridine-2-carboxamide;3-chloro-N-[3-chloro-4-(4-chloro-1,3-dioxoisoindol-2-yl)phenyl]pyridine-2-carboxamide;Inhibitor,inhibit,VU0483605,Metabotropic glutamate receptors,allosteric modulator,brain penetrant,metabotropic glutamate,VU 0483605,mGluR,VU-0483605
11 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Cayman Chemical
  • Chemenu
  • Crysdot
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberSYN5042
  • Product descriptionVU0483605
  • Packaging10mg
  • Price$175
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN5042
  • Product descriptionVU0483605
  • Packaging50mg
  • Price$585
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC5611
  • Product descriptionVU0483605
  • Packaging10mg
  • Price$171
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16941
  • Product descriptionVU0483605 ≥98%
  • Packaging1mg
  • Price$49
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16941
  • Product descriptionVU0483605 ≥98%
  • Packaging5mg
  • Price$96
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16941
  • Product descriptionVU0483605 ≥98%
  • Packaging10mg
  • Price$143
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM268069
  • Product description3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide 95%+
  • Packaging1g
  • Price$888
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD00008504
  • Product description3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide 97%
  • Packaging100mg
  • Price$236
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD00008504
  • Product description3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide 97%
  • Packaging250mg
  • Price$376
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD00008504
  • Product description3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide 97%
  • Packaging1g
  • Price$942
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberV787575
  • Product descriptionVU0483605
  • Packaging50mg
  • Price$550
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific SYN5042 VU0483605 10mg $175 2021-12-16 Buy
AK Scientific SYN5042 VU0483605 50mg $585 2021-12-16 Buy
ApexBio Technology C5611 VU0483605 10mg $171 2021-12-16 Buy
Cayman Chemical 16941 VU0483605 ≥98% 1mg $49 2024-03-01 Buy
Cayman Chemical 16941 VU0483605 ≥98% 5mg $96 2024-03-01 Buy
Cayman Chemical 16941 VU0483605 ≥98% 10mg $143 2024-03-01 Buy
Chemenu CM268069 3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide 95%+ 1g $888 2021-12-16 Buy
Crysdot CD00008504 3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide 97% 100mg $236 2021-12-16 Buy
Crysdot CD00008504 3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide 97% 250mg $376 2021-12-16 Buy
Crysdot CD00008504 3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide 97% 1g $942 2021-12-16 Buy
TRC V787575 VU0483605 50mg $550 2021-12-16 Buy

Properties

Density :1.625±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤20mg/ml in DMSO;20mg/ml in dimethyl formamide
form :crystalline solid
pka :9.39±0.70(Predicted)
color :Light yellow to orange

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Glutamate, the major excitatory neurotransmitter in the CNS, activates eight known subtypes of metabotropic glutamate receptors (mGluRs). Highly selective modulators designed to act at allosteric sites on certain mGluR subtypes are being developed to preferentially regulate subtype-specific, glutamate-induced receptor activation. VU0483605 is a selective positive allosteric modulator (PAM) of mGluR1, displaying EC50 values of 0.39 and 0.36 μM at human and rat receptors, respectively, and no activity as a mGlu4 PAM (EC50 >10 μM). It has been shown to potentiate a response to glutamate in wild-type cell lines stably expressing mGlu1 and to partially restore the reduction in glutamate-mediated calcium signaling in a mutant cell model of schizophrenia.

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