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ChemicalBook >> CAS DataBase List >> 5-Amino-3,4-dimethyl-thieno[2,3-c]pyridazine-6-carboxylic acid 4-trifluoromethanesulfonyl-benzylamide

5-Amino-3,4-dimethyl-thieno[2,3-c]pyridazine-6-carboxylic acid 4-trifluoromethanesulfonyl-benzylamide

5-Amino-3,4-dimethyl-thieno[2,3-c]pyridazine-6-carboxylic acid 4-trifluoromethanesulfonyl-benzylamide price.
  • $59 - $1200
  • Product name: 5-Amino-3,4-dimethyl-thieno[2,3-c]pyridazine-6-carboxylic acid 4-trifluoromethanesulfonyl-benzylamide
  • CAS: 1451993-15-9
  • MF: C17H15F3N4O3S2
  • MW: 444.45
  • EINECS:-0
  • MDL Number:
  • Synonyms:5-Amino-3,4-dimethyl-thieno[2,3-c]pyridazine-6-carboxylic acid 4-trifluoromethanesulfonyl-benzylamide;VU0467154;VU0467154, VU-0467154, VU 0467154;Thieno[2,3-c]pyridazine-6-carboxamide, 5-amino-3,4-dimethyl-N-[[4-[(trifluoromethyl)sulfonyl]phenyl]methyl]-;VUO467154 - M4 Receptor Agonist;VU0467154,Muscarinic acetylcholine receptor,VU 0467154,VU-0467154,mAChR,inhibit,Inhibitor;5-Amino-3,4-dimethyl-N-(4-((trifluoromethyl)sulfonyl)benzyl)thieno[2,3-c]pyridazine-6-carboxamide;VU0467154, 10 mM in DMSO
11 prices
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Brand
  • AK Scientific
  • Cayman Chemical
  • ChemScene
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • ManufacturerAK Scientific
  • Product number7603DW
  • Product descriptionCID73774630
  • Packaging1mg
  • Price$162
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number25555
  • Product descriptionVU0467154 ≥95%
  • Packaging1mg
  • Price$59
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number25555
  • Product descriptionVU0467154 ≥95%
  • Packaging5mg
  • Price$239
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number25555
  • Product descriptionVU0467154 ≥95%
  • Packaging10mg
  • Price$421
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number25555
  • Product descriptionVU0467154 ≥95%
  • Packaging25mg
  • Price$979
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0044134
  • Product descriptionVU0467154 99.59%
  • Packaging5mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0044134
  • Product descriptionVU0467154 99.59%
  • Packaging10mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0044134
  • Product descriptionVU0467154 99.59%
  • Packaging25mg
  • Price$290
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0044134
  • Product descriptionVU0467154 99.59%
  • Packaging50mg
  • Price$490
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0044134
  • Product descriptionVU0467154 99.59%
  • Packaging100mg
  • Price$850
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberV850025
  • Product descriptionVU0467154
  • Packaging100mg
  • Price$1200
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 7603DW CID73774630 1mg $162 2021-12-16 Buy
Cayman Chemical 25555 VU0467154 ≥95% 1mg $59 2024-03-01 Buy
Cayman Chemical 25555 VU0467154 ≥95% 5mg $239 2024-03-01 Buy
Cayman Chemical 25555 VU0467154 ≥95% 10mg $421 2024-03-01 Buy
Cayman Chemical 25555 VU0467154 ≥95% 25mg $979 2024-03-01 Buy
ChemScene CS-0044134 VU0467154 99.59% 5mg $110 2021-12-16 Buy
ChemScene CS-0044134 VU0467154 99.59% 10mg $150 2021-12-16 Buy
ChemScene CS-0044134 VU0467154 99.59% 25mg $290 2021-12-16 Buy
ChemScene CS-0044134 VU0467154 99.59% 50mg $490 2021-12-16 Buy
ChemScene CS-0044134 VU0467154 99.59% 100mg $850 2021-12-16 Buy
TRC V850025 VU0467154 100mg $1200 2021-12-16 Buy

Properties

Density :1.514±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO: Soluble
form :A solid
pka :11.80±0.46(Predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P307+P311, P321,P405, P501
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P272 Contaminated work clothing should not be allowed out of the workplace.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P341 IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P310 Immediately call a POISON CENTER or doctor/physician.
P321 Specific treatment (see … on this label).
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.
P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P363 Wash contaminated clothing before reuse.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor that potentiates acetylcholine responses in CHO cells expressing M4 receptors (EC50s = 17.7, 630, and 1,000 nM for rat, human, and cynomolgus monkey receptors, respectively). It is selective for M4 over M1-3 and M5 receptors and a panel of receptors, transporters, and cation channels when used at a concentration of 10 μM. In vivo, VU0467154 (3-56.6 mg/kg, p.o.) reverses amphetamine-induced hyperlocomotion in rats. It reverses MK-801-induced hyperlocomotion, deficits in a pairwise visual discrimination task, and impairments in the acquisition of contextual fear conditioning in wild-type, but not M4 knockout, mice. VU0467154 (3-30 mg/kg) also increases freezing behavior in contextual and tone fear conditioning tests in wild-type mice when administered prior to the conditioning session. Chronic administration of VU0467154 (10 mg/kg once daily) reduces motor incoordination and prevents decreases in locomotion in the YAC128 transgenic mouse model of Huntington''s disease.

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